Tlr2 - toll-like receptor 2 Gene

Also known as Ly105

About Tlr2

Summary

Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like Receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system Cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (Toll Like Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]