Bcl2l1 - Bcl2-like 1 Gene

Also Known as Bclx; Bcl2l; bcl-X; Bcl-xl

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24888

About Bcl2l1

Primary_assembly 3: 141,253,523-141,303,479 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 183 orthologues, 13 paralogues and is associated with 65 phenotypes. Biased expression in Thymus (RPKM 183.6), Kidney (RPKM 139.6) and 9 other tissues.

Summary

Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and positive regulation of transport. Located in cytosol; mitochondrial outer membrane; and presynapse. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; mental depression; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); pancreatic cancer; and stomach Cancer. Orthologous to human BCL2L1 (BCL2 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l1 Products (4)

mRNA Protein Name
NM_031535.2 NP_113723.2 bcl-2-like protein 1 isoform 1
NM_001033671.1 NP_001028843.1 bcl-2-like protein 1 isoform 3
NM_001033670.1 NP_001028842.1 bcl-2-like protein 1 isoform 2
NM_001033672.1 NP_001028844.1 bcl-2-like protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables GTPase binding IPI
IPI: Inferred from physical interaction
23792689 RGD
enables MDM2/MDM4 family protein binding IPI
IPI: Inferred from physical interaction
17060322 RGD
enables clathrin binding IPI
IPI: Inferred from physical interaction
23792689 RGD
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12097494 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9731710 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to astaxanthin IEP
IEP: Inferred from expression pattern
22889354 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
22158476 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
12904174 RGD
involved in cellular response to erythropoietin IEP
IEP: Inferred from expression pattern
22293409 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
20669351 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
20798690 RGD
involved in cellular response to nitric oxide IEP
IEP: Inferred from expression pattern
25726415 RGD
involved in cellular response to prolactin IEP
IEP: Inferred from expression pattern
12904174 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
21937453 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18483861 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9813151 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12097494 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22382519 RGD
involved in ovarian follicle development IMP
IMP: Inferred from mutant phenotype
17989359 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22158476 RGD
involved in positive regulation of synaptic vesicle clustering IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in positive regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
12515824 RGD
involved in regulation of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in regulation of synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
23792689 RGD
involved in regulation of synaptic vesicle endocytosis IEP
IEP: Inferred from expression pattern
23792689 RGD
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
17700647 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
20798690 RGD
involved in response to erythropoietin IEP
IEP: Inferred from expression pattern
18838949 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17869087 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17272823 RGD
involved in response to ischemia IDA
IDA: Inferred from direct assay
21410437 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
17912701 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18838949 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17805306 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
12721309 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
17728251 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11931842 RGD
involved in synaptic vesicle recycling via endosome IMP
IMP: Inferred from mutant phenotype
23792689 RGD
Cellular Component GO Annotation Evidence References Source
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
23792689 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
23792689 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
12515824 RGD
located in presynapse IDA
IDA: Inferred from direct assay
23792689 RGD
is active in synaptic vesicle IDA
IDA: Inferred from direct assay
23792689 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23792689 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l1 Protein Structure

bcl-2

bcl-2: TIGR00865 (0 - 187)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 1

  • B cell lymphoma 2 like

  • B cell lymphoma like X

  • apoptosis regulator Bcl-X

  • bcl2-L-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0420A Moroxydine hydrochloride Inhibitor 99.36% Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-N1423 Glycocholic acid 99.90% Phase 3
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 3
HY-10969A Obatoclax ≥99.0% Phase 3
HY-15464 (R)-(-)-Gossypol 99.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10969 Obatoclax Mesylate 99.85% Yes
HY-N1423A Glycocholic acid sodium 99.24% Unkown
HY-N1423S Glycocholic acid-d4 99.92% Unkown
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% Unkown
HY-153803 GBD-9 Degrader 99.91% Unkown
HY-W013105 Sodium glycocholate hydrate, 98% 99.91% Unkown
HY-132307 Mcl-1 inhibitor 6 98.77% Unkown
HY-N1423B Glycocholic acid hydrate 99.85% Unkown
HY-135273 A-1211212 98.43% Unkown
HY-19551 Apogossypolone 98.58% Unkown
HY-N1423S1 Glycocholic acid-d5 99.9% Unkown
HY-15191B (S)-Sabutoclax Inhibitor 98.03% Unkown
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / Unkown
HY-114310 VDR agonist 1 / Unkown
HY-123715 Anticancer agent 255 / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-147826 EGFR-IN-60 / Unkown
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / Unkown
HY-149681 Beclin1-Bcl-2 interaction inhibitor 1 Inhibitor / Unkown
HY-159513 Bcl-2/Mcl-1-IN-4 Inhibitor / Unkown
HY-161415 BCL-xL/BCL-2 ligand 1 / Unkown
HY-169083 Bcl-2-IN-22 Inhibitor / Unkown
HY-174338 GPER/Bcl-2-IN-1 Inhibitor / Unkown
HY-174403 c-MYC/BCL2 ligand 1 iodide / Unkown
HY-174404 Topoisomerase II inhibitor 23 / Unkown
HY-178910 Mcl-1-IN-20 / Unkown
HY-180371 NF-115 Inducer / Unkown
HY-181746 Bcl-2/Mcl-1-IN-5 / Unkown
HY-183369 VEGFR/PD-L1-IN-1 / Unkown
HY-N20627 Withametelin B / Unkown
HY-N3828 epi-Eriocalyxin A / Unkown
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / Unkown
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / Unkown
HY-W016937 Moroxydine Inhibitor / Unkown
HY-W713297 Moroxydine hydrochloride-d8 Inhibitor / Unkown
HY-W754548 Glycocholic acid-13C2,d4 / Unkown
HY-12011A (Rac)-HA14-1 Inhibitor / Unkown
HY-174635 Human IL15RA mRNA / Unkown
HY-N6926 1,3,5-Tricaffeoylquinic acid / Unkown
HY-N8579 Eugenyl benzoate ≥90.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l1 NCBI NCBI:598