2. Gene
  3. Bcl2l1 - Bcl2-like 1 Gene

Bcl2l1 - Bcl2-like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bclx; Bcl2l; bcl-X; Bcl-xl

Gene ID: 24888 | Gene type: protein coding

About Bcl2l1

Primary_assembly 3: 141,253,523-141,303,479 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 183 orthologues, 13 paralogues and is associated with 65 phenotypes. Biased expression in Thymus (RPKM 183.6), Kidney (RPKM 139.6) and 9 other tissues.

Summary

Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and positive regulation of transport. Located in cytosol; mitochondrial outer membrane; and presynapse. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; mental depression; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); pancreatic cancer; and stomach Cancer. Orthologous to human BCL2L1 (BCL2 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l1 Products(4)

mRNA Protein Name
NM_031535.2 NP_113723.2 bcl-2-like protein 1 isoform 1
NM_001033671.1 NP_001028843.1 bcl-2-like protein 1 isoform 3
NM_001033670.1 NP_001028842.1 bcl-2-like protein 1 isoform 2
NM_001033672.1 NP_001028844.1 bcl-2-like protein 1 isoform 1

Bcl2l1 Protein Structure

bcl-2

bcl-2: TIGR00865 (0 - 187)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 1

B cell lymphoma 2 like

B cell lymphoma like X

apoptosis regulator Bcl-X

bcl2-L-1

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-10969 Obatoclax Mesylate 99.74% Phase 3
HY-10969A Obatoclax / Phase 3
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2
HY-15464 (R)-(-)-Gossypol 98.82% Phase 2
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 98.78% Unkown
HY-132307 Mcl-1 inhibitor 6 98.40% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-135273 A-1211212 / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-147826 EGFR-IN-60 / Unkown
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / Unkown
HY-156877 Bcl-2-IN-16 / Unkown
HY-N10481 Aviculin / Unkown
HY-N3828 epi-Eriocalyxin A / Unkown
HY-N8579 Eugenyl benzoate / Unkown
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / Unkown
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / Unkown
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / Unkown
HY-15191B (S)-Sabutoclax Inhibitor 95.66% Unkown
HY-19551 Apogossypolone / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l1 NCBI NCBI:598