Ngf - nerve growth factor Gene

Also Known as Ngfb; beta-NGF

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310738

Summary

Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin Trk Receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Ngf Products (1)

mRNA Protein Name
NM_001277055.1 NP_001263984.1 beta-nerve growth factor precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
19129380 RGD
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
23934089 RGD
involved in cell proliferation in forebrain IMP
IMP: Inferred from mutant phenotype
29409115 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
19129380 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21541365 RGD
involved in negative regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22926925 RGD
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
23934089 RGD
involved in neuron projection development IDA
IDA: Inferred from direct assay
3336364 RGD
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19029245 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17310240 RGD
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
18973572 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18846328 RGD
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
18846328 RGD
acts upstream of or within positive regulation of neurotrophin TRK receptor signaling pathway IDA
IDA: Inferred from direct assay
19029245 RGD
acts upstream of or within positive regulation of protein autophosphorylation IDA
IDA: Inferred from direct assay
19029245 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
20605787 RGD
involved in positive regulation of stem cell proliferation IDA
IDA: Inferred from direct assay
18846328 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
19059440 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
19200610 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19012240 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18981959 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
19824047 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18818126 RGD
involved in response to ozone IEP
IEP: Inferred from expression pattern
21075861 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18756821 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18836171 RGD
involved in sensory perception of hot stimulus IDA
IDA: Inferred from direct assay
27392124 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
1315318 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19065562 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-nerve growth factor

  • nerve growth factor (beta polypeptide)

  • pro-nerve growth factor long

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-I0021 Bepotastine Antagonist 99.88% Unkown
HY-A0015 Bepotastine besilate Antagonist 99.77% Unkown
HY-B0446 Naphazoline hydrochloride 99.38% Unkown
HY-111326A Naphazoline nitrate 99.12% Unkown
HY-111326 Naphazoline 99.74% Unkown
HY-I0021A Bepotastine tosylate Antagonist / Unkown
HY-I0021R Bepotastine (Standard) Antagonist / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-17622 Tavilermide Agonist 99.57% Phase 3
HY-14604 Xaliproden hydrochloride 98.40% Phase 3
HY-119820 Xaliproden free base / Phase 3
HY-120251 Leteprinim Inhibitor / Phase 2
HY-171450 VMD-928 Inhibitor 98.12% Phase 2
HY-122616 PF-06273340 Inhibitor 98.8% Phase 1
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P99221 Tanezumab Antagonist 99.52% Phase 3
HY-P99195 Fasinumab Inhibitor 98.11% Phase 3
HY-P99200 Fulranumab Inhibitor 96.74% Phase 3
HY-P991324 MEDI-7352 Inhibitor / Phase 2
HY-P99627 Frunevetmab 95.00% Phase 1
HY-P990749 Luvagrobart Inhibitor 98.80% Phase 1

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18314 GW 441756 99.85% Unkown
HY-N6732 K-252a Inhibitor 99.45% Unkown
HY-108466 Ro 08-2750 Inducer 98.01% Unkown
HY-N6838 1,1,1,1-Kestohexaose 98.0% Unkown
HY-133968 24-Methylenecholesterol 99.78% Unkown
HY-N0380 Nardosinone Activator 99.81% Unkown
HY-N4285 Negletein 99.55% Unkown
HY-110166 PD 90780 98.83% Unkown
HY-120553 B-355252 Inhibitor 99.71% Unkown
HY-59201A A-582941 dihydrochloride 99.78% Unkown
HY-124637 ALE-0540 Antagonist 98.24% Unkown
HY-A0015A (Rac)-Bepotastine besilate Inhibitor 99.52% Unkown
HY-P3588 N-Acetyl semax amidate 99.60% Unkown
HY-P3709A TRAF6 peptide TFA Inhibitor 98.20% Unkown
HY-N15385 Hericenone D Inhibitor 98.20% Unkown
HY-117517 NG-012 Activator 96.1% Unkown
HY-120251A Leteprinim potassium Inhibitor 99.0% Unkown
HY-P10699 MAX1 95.31% Unkown
HY-P11480 TrkA/NGF-IN-1 Inhibitor 98.22% Unkown
HY-P3709 TRAF6 peptide Inhibitor / Unkown
HY-11055 KP 544 / Unkown
HY-116202 PACA Activator / Unkown
HY-124152 3,4-Dephostatin Inhibitor / Unkown
HY-130179 RC-33 hydrochloride Inducer / Unkown
HY-133968S1 24-Methylenecholesterol-13C / Unkown
HY-146523 TRK-IN-17 Inhibitor / Unkown
HY-146524 TRK-IN-18 Inhibitor / Unkown
HY-165616 NS 1231 / Unkown
HY-182401 NS-417 free base Activator / Unkown
HY-59201 A-582941 / Unkown
HY-A0015S Bepotastine-d6 besylate Antagonist / Unkown
HY-D2336 PROTAC Aster-A degrader-1 / Unkown
HY-E70785 TRKA G667C Recombinant Human Active Protein Kinase / Unkown
HY-E70869 TRKA(NTRK1) Recombinant Human Active Protein Kinase / Unkown
HY-N10325 Sarbronine M / Unkown
HY-N12170 Kissoone C / Unkown
HY-N12566 Erinacin B / Unkown
HY-N15532 Phenylmethyl 6-O-α-L-arabinofuranosyl-β-D-glucopyranoside Modulator / Unkown
HY-N18211 1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin / Unkown
HY-N3928 Garciniaxanthone E / Unkown
HY-N3938 Gelsemiol / Unkown
HY-P10140 JNK-IN-15, Cell-Permeable Inhibitor / Unkown
HY-P10141 JNK-IN-15, Cell-Permeable, Negative Control Inhibitor / Unkown
HY-P5156 BDS-I Inhibitor / Unkown
HY-P6299 MAX8 / Unkown
HY-RS09277 NGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182824 Sucrose dilaurate Inducer / Unkown
HY-N13170 Glycoside H2 / Unkown
HY-N14417 Indocarbazostatin / Unkown
HY-N14424 Indocarbazostatin B / Unkown
HY-NP144 Nerve Growth Factor 7S,murine submaxillary gland / Unkown
HY-RS16265 Ngf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22931 Ngf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99297 Bedinvetmab Inhibitor 99.80% Unkown
HY-P99677 Izenivetmab Inhibitor 95.00% Unkown
HY-P991622 MNAC13 Inhibitor / Unkown
HY-P991711 Povovetug Inhibitor 95.759% Unkown
HY-P990474 Anti-NGF/bNGF Antibody Inhibitor 99.65% Unkown
HY-P991323 MEDI-1912 Inhibitor / Unkown
HY-P991325 CRB-0089 Inhibitor / Unkown
HY-P992273 Anti-NGF2 Antibody / Unkown
HY-P992345 DS002 Inhibitor / Unkown
HY-P99820 Ranevetmab / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ngf NCBI NCBI:4803