2. Gene
  3. Hdac4 - histone deacetylase 4 Gene

Hdac4 - histone deacetylase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 363287 | Gene type: protein coding

About Hdac4

Primary_assembly 9: 92,507,611-92,750,164 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 263 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 6.6), Thymus (RPKM 53.6) and 9 other tissues.

Summary

Enables promoter-specific chromatin binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Located in cytosol; nucleus; and sarcomere. Part of protein-containing complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 Products(1)

mRNA Protein Name
NM_053449.1 NP_445901.1 histone deacetylase 4

Hdac4 Protein Structure

ClassIIa_HDAC4_Gln-rich-N

ClassIIa_HDAC4_Gln-rich-N: cd10162 (98 - 159)

HDAC4

HDAC4: cd10006 (660 - 1068)

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  • 1096 a.a.
Protein Preferred Names Protein Names

histone deacetylase 4

HD4

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-13322 Pracinostat Inhibitor 99.82% Yes
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-10528 Tasquinimod Modulator 99.94% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18361 TMP195 Inhibitor 99.57% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.05% Unkown
HY-13428 Tubacin Inhibitor 95.50% Unkown
HY-16699 Nexturastat A Inhibitor 99.03% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-19350 BML-210 Inhibitor 98.06% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-162377 HDAC-IN-70 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-149721 HDAC4-IN-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac4 NCBI NCBI:9759