Hdac4 - histone deacetylase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363287

About Hdac4

Primary_assembly 9: 92,507,611-92,750,164 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 263 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 6.6), Thymus (RPKM 53.6) and 9 other tissues.

Summary

Enables promoter-specific chromatin binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Located in cytosol; nucleus; and sarcomere. Part of protein-containing complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 Products (1)

mRNA Protein Name
NM_053449.1 NP_445901.1 histone deacetylase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
21586557 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21464227 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19261284 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
20097749 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
22389387 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
24166750 RGD
involved in positive regulation of male mating behavior IMP
IMP: Inferred from mutant phenotype
21586557 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
23925573 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
24166750 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
24166750 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
24166750 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
26509893 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
16767219 RGD
Cellular Component GO Annotation Evidence References Source
located in A band IDA
IDA: Inferred from direct assay
18250163 RGD
located in Z disc IDA
IDA: Inferred from direct assay
18250163 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
22360269 RGD
located in sarcomere IDA
IDA: Inferred from direct assay
18250163 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac4 Protein Structure

ClassIIa_HDAC4_Gln-rich-N

ClassIIa_HDAC4_Gln-rich-N: cd10162 (98 - 159)

HDAC4

HDAC4: cd10006 (660 - 1068)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1096 a.a.
Protein Preferred Names Protein Names

histone deacetylase 4

  • HD4

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-10528 Tasquinimod Modulator 99.70% Phase 3
HY-150109 Puzerinostat mesylate Inhibitor 99.45% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (61)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-19350 BML-210 Inhibitor 98.04% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-169259 HDAC9-IN-1 Inhibitor 95.13% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-W039803 HDAC4 ligand-2 Ligand / Unkown
HY-149721 HDAC4-IN-1 Inhibitor 98.11% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-184524 PROTAC HDAC4 Degrader-2 / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-181086 FLT3/HDAC-IN-3 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-172159 FF2039 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-179321 PROTAC HDAC4 Degrader-1 Degrader / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-184705 HDAC-IN-105 Inhibitor / Unkown
HY-178022 HDAC6-IN-63 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-P2044 Azumamide E Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac4 NCBI NCBI:9759