PDK1 - pyruvate dehydrogenase kinase 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5163

About PDK1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:172,555,373-172,724,312 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 4.7), adrenal (RPKM 4.3) and 25 other tissues.

Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major Enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

PDK1 Products (36)

mRNA Protein Name
XR_427093.4
XM_047444740.1 XP_047300696.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X7
XR_007076392.1
XR_007076402.1
NR_103729.2
XR_001738771.2
XR_922944.3
XR_007076401.1
XR_007076399.1
XR_922945.1
XR_007076391.1
XR_007076400.1
XR_007076403.1
XM_006712594.3 XP_006712657.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X6
XR_922942.2
XR_007076393.1
XM_047444736.1 XP_047300692.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XM_011511344.3 XP_011509646.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XR_007076398.1
XM_047444739.1 XP_047300695.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X5
XR_001738775.3
XR_922943.2
XR_007076394.1
XM_011511347.3 XP_011509649.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1
XM_047444737.1 XP_047300693.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X3
XM_011511345.4 XP_011509647.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2
XR_007076395.1
XR_001738774.3
XR_001738772.3
XR_007076396.1
XR_007076397.1
NR_103731.1
NM_001278549.2 NP_001265478.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor
XM_047444738.1 XP_047300694.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X4
NM_002610.5 NP_002601.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2 precursor
XM_011511343.3 XP_011509645.1 pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7782287 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
17683942 GOA
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA
IDA: Inferred from direct assay
7499431 GOA
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IMP
IMP: Inferred from mutant phenotype
22195962 GOA
Biological Process GO Annotation Evidence References Source
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
18541534 GOA
involved in hypoxia-inducible factor-1alpha signaling pathway IMP
IMP: Inferred from mutant phenotype
21763680 GOA
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
18541534 GOA
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
18541534 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDK1 Protein Structure

BCDHK_Adom3

BCDHK_Adom3: Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (56 - 220)

HATPase_c

HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (269 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
Protein Preferred Names Protein Names

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

  • PDH kinase 1

  • mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1

  • pyruvate dehydrogenase kinase, isoenzyme 1

PDK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDK1 Q15118 PKN2 Homo sapiens Q16513
Protein Kinase Assay
17110931
Intra
PDK1 Q15118 PDHA1 Homo sapiens P08559
Enzymatic Study
7782287
Intra
PDK1 Q15118 PDHA1 Homo sapiens P08559
BioID
29568061
Cross: Cross-species interaction Intra: Intraspecies interaction

PDK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80272 PDK1 Antibody (YA236) WB, IHC-P, IP, FC Human, Mouse, Rat
HY-P84583 PDK1 Antibody (YA4280) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat, Monkey
HY-P84583A PDK1 Antibody (YA4280)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Rat, Monkey
HY-P85321 PDK1 Antibody (YA5013) WB; IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Protection Against

  • Lung Cancer, Susceptibility To

  • Adenocarcinoma Of Lung, Somatic

  • Nonsmall Cell Lung Cancer

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0645 Dicoumarol Inhibitor 99.89% Unkown
HY-124060 PS423 99.38% Unkown

Pre-clinical Phase

Bioactive Molecules (56)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10514 BX795 99.84% Unkown
HY-14981 GSK2334470 Inhibitor 99.79% Unkown
HY-N0047 Polyphyllin I 99.91% Unkown
HY-11005 BX-912 99.50% Unkown
HY-15967 PS48 Activator 99.71% Unkown
HY-12492 VER-246608 Inhibitor 99.10% Unkown
HY-121744 PS10 Inhibitor 98.51% Unkown
HY-10547 OSU-03012 99.80% Unkown
HY-124379 TPCK 98.55% Unkown
HY-19564 JX06 99.78% Unkown
HY-N6769 Radicicol Inhibitor 99.96% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-14440 MP7 Inhibitor 99.33% Unkown
HY-13842 BX517 Inhibitor 98.0% Unkown
HY-106263B Tyroserleutide hydrochloride 99.92% Unkown
HY-121629 PS210 Activator 98.30% Unkown
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% Unkown
HY-114645 PDK1-IN-RS2 Inhibitor 98.49% Unkown
HY-149814 PDK-IN-1 Inhibitor 99.74% Unkown
HY-157299 PDK-IN-3 Inhibitor 99.87% Unkown
HY-10515 BX-320 Inhibitor 99.4% Unkown
HY-13851 PS47 99.13% Unkown
HY-P5450A PDKtide TFA 99.07% Unkown
HY-W998345 SMART1 Inhibitor 99.87% Unkown
HY-117809 PDK1-IN-2 Inhibitor 98.90% Unkown
HY-13856 (R)-PS210 Inhibitor 98.09% Unkown
HY-151466 HIF-1α-IN-5 Inhibitor 99.95% Unkown
HY-W070306 PDK1-IN-1 Inhibitor 99.95% Unkown
HY-129426 PDK1/Akt/Flt dual pathway inhibitor Inhibitor / Unkown
HY-151465 HIF-1α-IN-4 Inhibitor 99.95% Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-W837864 PDK1 allosteric modulator 1 Modulator 99.34% Unkown
HY-119134 PX-316 Inhibitor / Unkown
HY-124288 PDK1/AurA-IN-1 / Unkown
HY-12482 X-370 / Unkown
HY-135773 CRTh2 antagonist 3 / Unkown
HY-13844 PDK1-IN-3 Inhibitor / Unkown
HY-149275 PKM2/PDK1-IN-1 / Unkown
HY-156109 PDK-IN-2 / Unkown
HY-16461 Solenopsin / Unkown
HY-172142 PDK1-IN-4 Inhibitor / Unkown
HY-177913 OSU-02067 Inhibitor / Unkown
HY-179501 PDK1-IN-5 / Unkown
HY-181670 WH23 / Unkown
HY-183583 HIF-2α-IN-18 Inhibitor / Unkown
HY-N0645S Dicoumarol-d8 / Unkown
HY-N17990 Sexangularetin 3-sophoroside / Unkown
HY-P5450 PDKtide / Unkown
HY-RS10273 PDK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10274 Pdk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10275 Pdk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10287 PDPK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W074538 3-Amino-5-(2-furyl)pyrazole / Unkown
HY-117885 PF-5177624 Inhibitor / Unkown
HY-175770 mIDH1-IN-2 / Unkown
HY-RS17027 Pdpk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDK1 VGNC VGNC:97211
Rattus norvegicus PDK1 RGD RGD:69427
Felis catus PDK1 VGNC VGNC:68775
Bos taurus PDK1 VGNC VGNC:32703
Macaca mulatta PDK1 VGNC VGNC:75932
Mus musculus PDK1 MGD MGI:1926119
Others PDK1 NCBI