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Ghsr - growth hormone secretagogue receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84022

About Ghsr

Primary_assembly 2: 110,268,489-110,271,865 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 218 orthologues, 14 paralogues and is associated with 34 phenotypes. Biased expression in Testes (RPKM 7.) and Brain (RPKM 3.).

Summary

Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including regulation of digestive system process; regulation of secretion by cell; and response to peptide hormone. Acts upstream of or within negative regulation of Insulin secretion. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is integral component of synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghsr Products (1)

mRNA	Protein	Name
NM_032075.3	NP_114464.1	growth hormone secretagogue receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth hormone secretagogue receptor activity	IDA IDA: Inferred from direct assay	9092793	RGD
enables growth hormone secretagogue receptor activity	IMP IMP: Inferred from mutant phenotype	17109695	RGD
enables hormone binding	IPI IPI: Inferred from physical interaction	10604470	RGD
enables peptide hormone binding	IMP IMP: Inferred from mutant phenotype	17109695	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10604470	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9092793	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	15680488	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	15155262	RGD
involved in cellular response to thyroid hormone stimulus	IEP IEP: Inferred from expression pattern	11207942	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	20814072	RGD
involved in ghrelin secretion	IMP IMP: Inferred from mutant phenotype	21778696	RGD
involved in learning or memory	IDA IDA: Inferred from direct assay	19652956	RGD
involved in negative regulation of appetite	IMP IMP: Inferred from mutant phenotype	21778696	RGD
acts upstream of or within negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	17130496	RGD
involved in negative regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	19931319	RGD
involved in negative regulation of macrophage apoptotic process	IMP IMP: Inferred from mutant phenotype	25337654	RGD
involved in negative regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	17911350	RGD
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17911350	RGD
involved in positive regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	26512025	RGD
involved in positive regulation of fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	12045256	RGD
involved in positive regulation of growth	IMP IMP: Inferred from mutant phenotype	12045256	RGD
involved in positive regulation of small intestinal transit	IMP IMP: Inferred from mutant phenotype	15890336	RGD
involved in positive regulation of small intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	15890336	RGD
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	21642627	RGD
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21642627	RGD
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	26153524	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26153524	RGD
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	12045256	RGD
involved in regulation of gastric motility	IMP IMP: Inferred from mutant phenotype	23525979	RGD
involved in regulation of growth hormone secretion	IMP IMP: Inferred from mutant phenotype	12045256	RGD
involved in regulation of hindgut contraction	IMP IMP: Inferred from mutant phenotype	16873401	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP EXP: Inferred from Experiment	24367106	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	24367106	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	24367106	RGD
involved in regulation of postsynapse organization	EXP EXP: Inferred from Experiment	22516464	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	22516464	RGD
involved in regulation of transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	23525979	RGD
involved in response to L-glutamate	IEP IEP: Inferred from expression pattern	10718930	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	10844575	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	24473434	RGD
involved in response to follicle-stimulating hormone	IEP IEP: Inferred from expression pattern	12606422	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	9822798	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12606422	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	26153524	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26153524	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	22516464	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22516464	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24367106	RGD
is active in synaptic membrane	IDA IDA: Inferred from direct assay	24367106	RGD
is active in synaptic membrane	IMP IMP: Inferred from mutant phenotype	24367106	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ghsr Protein Structure

7tmA_GHSR

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
growth hormone secretagogue receptor type 1	GH-releasing peptide receptor GHRP GHS-R ghrelin receptor

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14734	Anamorelin	Agonist	99.94%	Unkown
HY-14734A	Anamorelin hydrochloride	Agonist	99.59%	Unkown
HY-14820A	Macimorelin acetate	Agonist	99.34%	Yes
HY-14820	Macimorelin	Agonist	/	Unkown
HY-14734B	Anamorelin Fumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14903	Ulimorelin	Agonist	96.10%	Phase 3
HY-19884	Relamorelin	Agonist	/	Phase 3
HY-P5645	LEAP-2	Antagonist	98.55%	Phase 2
HY-12584	PF-5190457	Inhibitor	99.26%	Phase 2
HY-10199A	Ibutamoren	Agonist	99.84%	Phase 2
HY-15243	Capromorelin Tartrate	Agonist	98.10%	Phase 2
HY-15242	Capromorelin	Activator	/	Phase 2
HY-P0231	AZP-531		99.36%	Phase 1
HY-10957	L-692429	Agonist	99.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (59)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50844	Ibutamoren Mesylate	Agonist	99.86%	Unkown
HY-U00433	JMV 2959	Antagonist	99.91%	Unkown
HY-13964A	YIL781 hydrochloride	Antagonist	99.48%	Unkown
HY-19884B	Relamorelin TFA	Agonist	99.16%	Unkown
HY-P1366	des-Gln14-Ghrelin		98.21%	Unkown
HY-P10283	S1H	Antagonist	99.32%	Unkown
HY-13964	YIL781	Antagonist	99.68%	Unkown
HY-N3297	Meranzin hydrate	Modulator	99.89%	Unkown
HY-171962A	KARI 201 hydrochloride	Agonist	99.94%	Unkown
HY-U00433A	JMV 2959 hydrochloride	Antagonist	98.09%	Unkown
HY-P1155	GRF (1-29) amide (rat)	Inducer	99.80%	Unkown
HY-P1139	Cortistatin-8	Antagonist	99.56%	Unkown
HY-P1421	Obestatin(human)	Inhibitor	99.74%	Unkown
HY-50760	L-692585	Agonist	98.94%	Unkown
HY-N12348	Emoghrelin	Activator	95.46%	Unkown
HY-12584A	(S)-PF-5190457		99.27%	Unkown
HY-116625	PF-04628935	Antagonist	99.58%	Unkown
HY-P4750	Acetyl-(D-Arg2)-GRF (1-29) amide (human)	Antagonist	99.67%	Unkown
HY-113906A	(αR,8aS)-GSK1614343	Control	99.72%	Unkown
HY-P3596A	GHRF, mouse TFA	Agonist	98.87%	Unkown
HY-N3298	Meranzin	Modulator	98.0%	Unkown
HY-P1547	Somatostatin-25	Inhibitor	96.77%	Unkown
HY-P4405	(D-Ala2)-GRF (1-29) amide (human)	Agonist	98.83%	Unkown
HY-19884A	Relamorelin acetate	Agonist	/	Unkown
HY-137061	AZ-GHS-22	Antagonist	/	Unkown
HY-P1432A	K-(D-1-Nal)-FwLL-NH2 TFA	Antagonist	/	Unkown
HY-P10964	Tezusomant	Antagonist	/	Unkown
HY-176995	AZ-GHS-38	Agonist	/	Unkown
HY-117584	L-163255 free base		/	Unkown
HY-P1432	K-(D-1-Nal)-FwLL-NH2	Antagonist	/	Unkown
HY-P1306	Obestatin(rat)		98.73%	Unkown
HY-P3607	GHRF, bovine	Activator	/	Unkown
HY-115272	GSK894490A	Agonist	/	Unkown
HY-171962	KARI 201	Agonist	/	Unkown
HY-186165	KARI 101	Agonist	/	Unkown
HY-157556	BPP-2		/	Unkown
HY-P3056	GHRF, ovine		/	Unkown
HY-145364	Ghrelin receptor full agonist-2	Agonist	/	Unkown
HY-100305	Substituted piperidines-1	Agonist	/	Unkown
HY-P1306A	Obestatin(rat) TFA		/	Unkown
HY-113906	GSK1614343	Antagonist	/	Unkown
HY-14495A	BMS-604992 free base	Agonist	/	Unkown
HY-119125	BMS-317180	Agonist	/	Unkown
HY-153095	PF-6870961	Agonist	/	Unkown
HY-P1366A	des-Gln14-Ghrelin TFA		/	Unkown
HY-19454	CP-464709	Agonist	/	Unkown
HY-14495B	BMS-604992 dihydrochloride	Agonist	/	Unkown
HY-153095A	PF-6870961 hydrochloride	Agonist	/	Unkown
HY-118995	L-739943	Activator	/	Unkown
HY-P3596	GHRF, mouse		/	Unkown
HY-14495	BMS-604992	Agonist	/	Unkown
HY-173271	GHSR-1a agonist-1	Agonist	/	Unkown
HY-111232	GSK894281	Agonist	/	Unkown
HY-10957A	L-692429 hydrochloride	Agonist	/	Unkown
HY-180210	Ghrelin receptor full agonist-3	Agonist	/	Unkown
HY-129287	JMV 3008	Antagonist	/	Unkown
HY-P10673	KwFwLL-NH2	Antagonist	/	Unkown
HY-129207	JMV 3002		/	Unkown
HY-116959	SM-130686		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ghsr	NCBI	NCBI:2693