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  3. Heterophyllin B

Heterophyllin B 

Cat. No.: HY-N1476
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Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer.

For research use only. We do not sell to patients.

Heterophyllin B Chemical Structure

Heterophyllin B Chemical Structure

CAS No. : 145459-19-4

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Description

Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer[1].

In Vitro

Heterophyllin B (0-200 µM; 12-48 hours) reduces cell viability in the 75, 100 and 200 µM groups, has no effect on 5, 10, 25 and 50 µM groups[1].
Heterophyllin B (0-50 µM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells[1].

Cell Viability Assay[1]

Cell Line: ECA-109 cells
Concentration: 5 µM, 10 µM, 25 µM, 50 µM, 75 µM, 100 µM and 200 µM
Incubation Time: 12, 24 and 48 hours
Result: Decreased cell viability at high concentrations.

Western Blot Analysis[1]

Cell Line: ECA-109 cells
Concentration: 0 µM, 10 µM, 25 µM, 50 µM
Incubation Time: 6 hours
Result: Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin.
Molecular Weight

778.94

Formula

C₄₀H₅₈N₈O₈

CAS No.

145459-19-4

SMILES

O=C([[email protected]@](CCC1)([H])N1C([[email protected]](NC(CNC(CNC2=O)=O)=O)([H])CC(C)C)=O)N(CCC3)[[email protected]]3([H])C(N(CCC4)[[email protected]]4([H])C(N[[email protected]@](C(N[[email protected]]2CC5=CC=CC=C5)=O)([H])[[email protected]@H](C)CC)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Heterophyllin BPI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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