Cat. No.: HY-N7036

Rhamnetin

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity.

For research use only. We do not sell to patients.

Purity: 99.18%
CAS No.: 90-19-7
Formula: C₁₆H₁₂O₇
Molecular Weight:316.27

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Rhamnetin Chemical Structure

CAS No.: 90-19-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Phospholipase Isoforms :

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	7.8 μM Compound: 3	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19278239]
Monocyte	IC₅₀	22 μM Compound: Rhamnetin	Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA	[PMID: 10096854]

In Vitro

Rhamnetin (0-10 μM, 24-48 h) inhibits the proliferation of cancer cell SKOV3 with an an IC₅₀ of 1.22 μM (24 h)^[2].
Rhamnetin (0-10 μM, 24 h) arrests the cell cycle of SKOV3 at G1 phase, and induces apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

SKOV3
Concentration:

0-10 μM
Incubation Time:

24-48 h
Result:

Inhibited the cell viability of SKOV3.

Cell Cycle Analysis^[2]

Cell Line:

SKOV3
Concentration:

0-10 μM
Incubation Time:

24 h
Result:

Arrested the cell cycle at G1 phase.

In Vivo

Rhamnetin (50-200 mg/kg, ip, once daily for 21 days) improves cognitive dysfunction after traumatic brain injury in rats and inhibits inflammatory response and oxidative stress in the hippocampus^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rat traumatic brain injury model^[3]
Dosage:

50-200 mg/kg
Administration:

ip, once daily for 21 days
Result:

Improved the spatial learning and memory ability of rats.
Reduced the levels of TNF-α, IL-1β, IL-6, IL-8, hs-CRP, MDA and H₂O₂ in the hippocampus.
Increased the levels of IL-10, SOD, GSH-Px in the hippocampus.

Chemical Information

CAS No. 90-19-7
Appearance Solid
Molecular Weight 316.27
Formula C₁₆H₁₂O₇
Color White to yellow
SMILES

OC1=C(C2=CC=C(O)C(O)=C2)OC3=C(C(O)=CC(OC)=C3)C1=O
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
- Plants
- Umbelliferae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Chem Biodivers

Rhamnetin Identified as a Potent Multidrug Resistance Reversal Agent From Xinjiang Euphorbia: Integrated Network Pharmacology, Molecular Simulation, and In Vitro Validation. [Abstract]

2026 Apr;23(4):e01952. PMID: 42037539
SSRN

2025 May 7.

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (632.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1619 mL

15.8093 mL

31.6186 mL

5 mM

0.6324 mL

3.1619 mL

6.3237 mL

10 mM

0.3162 mL

1.5809 mL

3.1619 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22(9). [Content Brief]

[2]. Bharadwaj KK, et al., Rhamnetin, a nutraceutical flavonoid arrests cell cycle progression of human ovarian cancer (SKOV3) cells by inhibiting the histone deacetylase 2 protein. J Biomol Struct Dyn. 2024;42(24):13421-13436. [Content Brief]

[3]. Zhang W, et al., Rhamnetin attenuates cognitive deficit and inhibits hippocampal inflammatory response and oxidative stress in rats with traumatic brain injury. Cent Eur J Immunol. 2015;40(1):35-41. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1619 mL	15.8093 mL	31.6186 mL	79.0464 mL
	5 mM	0.6324 mL	3.1619 mL	6.3237 mL	15.8093 mL
	10 mM	0.3162 mL	1.5809 mL	3.1619 mL	7.9046 mL
	15 mM	0.2108 mL	1.0540 mL	2.1079 mL	5.2698 mL
	20 mM	0.1581 mL	0.7905 mL	1.5809 mL	3.9523 mL
	25 mM	0.1265 mL	0.6324 mL	1.2647 mL	3.1619 mL
	30 mM	0.1054 mL	0.5270 mL	1.0540 mL	2.6349 mL
	40 mM	0.0790 mL	0.3952 mL	0.7905 mL	1.9762 mL
	50 mM	0.0632 mL	0.3162 mL	0.6324 mL	1.5809 mL
	60 mM	0.0527 mL	0.2635 mL	0.5270 mL	1.3174 mL
	80 mM	0.0395 mL	0.1976 mL	0.3952 mL	0.9881 mL
	100 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.7905 mL

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Rhamnetin

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Medicine Food Homology Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Lipid Metabolism Compound Library

Food-Sourced Compound Library

Anti-Liver Cancer Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Osteogenesis Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

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Multi-Target Compound Library

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Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

Miao Ethnicity Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

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High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Rhamnetin

All Phospholipase Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Rhamnetin Related Classifications

HY-N7036 Related Classifications