Indirubin-5-sulfonate
Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β.
For research use only. We do not sell to patients.
- CAS No.: 244021-67-8
- Formula: C16H10N2O5S
- Molecular Weight:342.33
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-10182B
Laduviglusib trihydrochlorideGSK-3α/β Inhibitor -
HY-19807
Indirubin-3'-monoximeGSK-3β Inhibitor -
HY-129492
GNF4877DYRK1A/GSK3β Inhibitor -
HY-12012
SB 216763Autophagy Inducer -
HY-12302
KenpaulloneCDK1/GSK-3β Inhibitor -
HY-15356
BIO-acetoxime -
HY-15504A
RGB-286638 free baseCDK/MAPK9 Inhibitor -
HY-15504
RGB-286638CDK/MAPK9 Inhibitor -
HY-124719
hSMG-1 inhibitor 11jhSMG-1 Inhibitor -
HY-10182A
Laduviglusib monohydrochlorideGSK-3α/β Inhibitor -
HY-13076
CHIR-98014GSK-3 Inhibitor -
HY-134622
GSK-3/CDK5/CDK2-IN-1GSK-3/CDK5/CDK2 Inhibitor
Biological Activity
Description
IC50 & Target
[1]|
Cdk1/cyclin B 55 nM (IC50) |
cdk2/cyclin A 35 nM (IC50) |
CDK2/cyclinE 150 nM (IC50) |
Cdk4/cyclin D1 300 nM (IC50) |
CDK5/p35 65 nM (IC50) |
GSK-3β |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | IC50 |
0.055 μM
Compound: 19
|
Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
|
[PMID: 34161865] |
Chemical Information
-
CAS No. 244021-67-8
-
Molecular Weight 342.33
-
Formula C16H10N2O5S
-
SMILES
O=S(C1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C/3=O)=O)C=C1)(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [Content Brief]
[2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indirubin-5-sulfonate Related Classifications
HY-111932 Related Classifications
Powered by Bioz