Azaserine
Based on 5 publication(s) in Google Scholar
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.57%
- CAS 番号: 115-02-6
- 分子式: C5H7N3O4
- 分子量:173.13
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells[2].
Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month
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Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
化学情報
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CAS 番号 115-02-6
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性状 Solid
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分子量 173.13
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分子式 C5H7N3O4
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Color White to off-white
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SMILES
N[C@@H](COC(C=[N+]=[N-])=O)C(O)=O
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別名
アザセリン; CI-337; O-Diazoacetyl-L-serine; P-165
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Rep
2024 Jan 30;43(2):113724. PMID: 38294905 -
Acta Biochim Biophys Sin (Shanghai)
2023 Mar 20;55(8):1288-1300. PMID: 36942991
Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300. [Abstract]
Fluorescence images of BODIPY-C11-stained SW1990 pancreatic cancer cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or medium containing 2 mM glutamine supplemented with 50 μM diazooxonorleucine (Don) or 10 μM Azaserine (Aza). Cells treated with 10 μM RSL3 or 20 μM erastin were used as positive controls. Blue, DAPI; green, BODIPY-C11 (oxidized).
Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300. [Abstract]
Fluorescence images of BODIPY-C11-stained SU.8686 pancreatic cancer cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or medium containing 2 mM glutamine supplemented with 50 μM diazooxonorleucine (Don) or 10 μM Azaserine (Aza). Cells treated with 10 μM RSL3 or 20 μM erastin were used as positive controls. Blue, DAPI; green, BODIPY-C11 (oxidized).
Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300. [Abstract]
Proportion of BODIPY-C11 evaluated by flow cytometry in SU.8686 cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or media containing 2 mM glutamine supplemented with 50 μM Don or 10 μM Azaserine.
Azaserine purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(8):1288-1300. [Abstract]
Proportion of BODIPY-C11 evaluated by flow cytometry in SW1990 cells cultured for 48 h in glutamine-free medium, medium containing 2 mM glutamine, or media containing 2 mM glutamine supplemented with 50 μM Don or 10 μM Azaserine.
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Vet Med Sci
Glucose Transport by Follicle-Stimulating Hormone Is Mediated Through the Akt/FOXO1 Pathway in Ovine Granulosa Cells. [Abstract]2025 Mar;11(2):e70294. PMID: 40065595
Azaserine purchased from MedChemExpress. Usage Cited in: Vet Med Sci. 2025 Mar;11(2):e70294. [Abstract]
To study the effect of glucose on the development of GCs as mediated by GLUT, the glucose inhibitor Azaserine (5 µM) was added to GC cultures, which eliminated the FSH-induced glucose uptake capacity of the GCs.
Azaserine purchased from MedChemExpress. Usage Cited in: Vet Med Sci. 2025 Mar;11(2):e70294. [Abstract]
Azaserine (5 μM) significantly reduced the viability of the GCs.
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Res Sq
De novo purine synthesis reprograms the macrophage inflammatory response and the immune response in sepsis. [Abstract]2026 Feb 19:rs.3.rs-8887742. PMID: 41756441 -
溶剤 & 溶解度
H2O : 50 mg/mL (288.80 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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参考文献
[1]. Longnecker DS, Curphey TJ. Adenocarcinoma of the pancreas in azaserine-treated rats. Cancer Res. 1975 Aug;35(8):2249-58. [Content Brief]
[3]. Williams MV, Tritz GJ. Studies on the modes of action of azaserine inhibition of Escherichia coli. Potentiation of phenylalanine reversal. J Antimicrob Chemother. 1977 Jan;3(1):65-77. [Content Brief]
[4]. Catane R, et al. Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity. Cancer Treat Rep. 1979 Jun;63(6):1033-8. [Content Brief]
[5]. Lyons SD, et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265(19):11377-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.7760 mL | 28.8800 mL | 57.7601 mL | 144.4002 mL |
| 5 mM | 1.1552 mL | 5.7760 mL | 11.5520 mL | 28.8800 mL | |
| 10 mM | 0.5776 mL | 2.8880 mL | 5.7760 mL | 14.4400 mL | |
| 15 mM | 0.3851 mL | 1.9253 mL | 3.8507 mL | 9.6267 mL | |
| 20 mM | 0.2888 mL | 1.4440 mL | 2.8880 mL | 7.2200 mL | |
| 25 mM | 0.2310 mL | 1.1552 mL | 2.3104 mL | 5.7760 mL | |
| 30 mM | 0.1925 mL | 0.9627 mL | 1.9253 mL | 4.8133 mL | |
| 40 mM | 0.1444 mL | 0.7220 mL | 1.4440 mL | 3.6100 mL | |
| 50 mM | 0.1155 mL | 0.5776 mL | 1.1552 mL | 2.8880 mL | |
| 60 mM | 0.0963 mL | 0.4813 mL | 0.9627 mL | 2.4067 mL | |
| 80 mM | 0.0722 mL | 0.3610 mL | 0.7220 mL | 1.8050 mL | |
| 100 mM | 0.0578 mL | 0.2888 mL | 0.5776 mL | 1.4440 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Azaserine 関連分類
HY-B0919 関連分類
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