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チゲサイクリン

(別名: Tigecycline; GAR-936)
43 Cited Publications
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Based on 43 publication(s) in Google Scholar

Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively.

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  • 純度: 99.95%
  • CAS 番号: 220620-09-7
  • 分子式: C29H39N5O8
  • 分子量:585.65
  • 保管条件:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Tigecycline Chemical Structure
    Tigecycline 構造式
  • Experimental Validation Results for Tigecycline
  • Experimental Validation Results for Tigecycline
  • Experimental Validation Results for Tigecycline
  • Experimental Validation Results for Tigecycline
  • Experimental Validation Results for Tigecycline
  • Experimental Validation Results for Tigecycline
CAS 番号: 220620-09-7
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  • Tigecycline Chemical Structure
    Tigecycline Chemical Structure
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    Tigecycline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 28;15(1):5481. [Abstract]

    Customer Validation
     Cell viability of HEK293T cells in the presence of increasing concentrations of Tigecycline (0.1-100 μM; 72 h), as measured by CCK-8 assay. Error bars (standard deviation) were calculated from three different experimental units (n = 3 independent experiments), and data were presented as mean values +/− SD.

  • 1/16

    Tigecycline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 28;15(1):5481. [Abstract]

    Customer Validation
     De novo mitochondrial and cytoplasmic nascent protein synthesis were measured by L-AHA labeling, followed by visualization of Alexa Fluor 488 fluorescence signal conjugated to L-AHA by “click reaction”. The intensity of the corresponding lines in the SDS-PAGE was analyzed using the ImageJ software. To estimate the IC50 value of Tigecycline (Tig, 0.1-5 μM) on the 55S mitoribosome in the mitochondrial lysate (Mito) and 80S human ribosome in the cytosolic lysate (Cyto), the intensities of positive controls derived from chloramphenicol (Cam) and CHX-treated samples, respectively, were subtracted. Second, the resulting intensities were normalized to the intensities of the negative controls, which in both cases were from the samples not treated with Tigecycline. Note that Tigecycline cannot sufficiently inhibit cytoplasmic translation even at high concentrations.

  • 1/16

    Tigecycline purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]

    Customer Validation
     Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

  • 1/16

    Tigecycline purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Apr;78:103943. [Abstract]

    Customer Validation
     Tigecycline (4 μg/mL). Time-killing curves of tet(X3)-positive strains (E. coli DH5α+pAM401-tet(X3)), E. coli 47EC, and A. baumannii 34AB) with the indicated treatment. The bacterial CFUs per mL at different time points over 24 h were determined by plating.

  • 1/16

    Tigecycline purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Feb 14;11(1):e0323822. [Abstract]

    Customer Validation
     The MIC distributions of Tigecycline against 43 M. fortuitum isolates (incubate for 24 h). The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

  • 1/16

    Tigecycline purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2018 Aug;52(2):269-271. [Abstract]

    Customer Validation
     Minimum inhibitory concentration (MIC) range as well as MIC50 and MIC90 values of the antibiotics tested against 121 Acinetobacter baumannii isolates from Greek hospitals.

  • Tigecycline