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Ac-DEVD-CHO TFA

47 Cited Publications
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Based on 47 publication(s) in Google Scholar

Ac-DEVD-CHO TFA is a peptide inhibitor of caspase-3 (Ki=230 pM) and caspase-7. Ac-DEVD-CHO TFA reduces caspase-3 activity and apoptosis induced by Prostaglandin E2 (HY-101952) in rat cortical neurons. Ac-DEVD-CHO TFA is promising for research of neurodegenerative diseases and cancers.

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  • 分子式: C22H31F3N4O13
  • 分子量:616.50
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Ac-DEVD-CHO TFA Chemical Structure
    Ac-DEVD-CHO TFA 構造式
  • Experimental Validation Results for Ac-DEVD-CHO TFA
  • Experimental Validation Results for Ac-DEVD-CHO TFA
  • Experimental Validation Results for Ac-DEVD-CHO TFA
  • Experimental Validation Results for Ac-DEVD-CHO TFA
  • Experimental Validation Results for Ac-DEVD-CHO TFA
  • Experimental Validation Results for Ac-DEVD-CHO TFA
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  • Ac-DEVD-CHO TFA Chemical Structure
    Ac-DEVD-CHO TFA Chemical Structure
    1/16
  • 1/16

    Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 May 16;11(20):eadq3870. [Abstract]

    Customer Validation
     Ac-DEVD-CHO (DEVD) (50 μM) rescued 4T1 cells from MCMSFT-induced cell death.

  • 1/16

    Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Mar 1;12(3):e008054. [Abstract]

    Customer Validation
     Ac-DEVD-CHO (100 µM; 4 h), a specific inhibitor of CASP3, prevented the activation of CASP3 and inhibited the cleavage of GSDME in CT26 and HCT116 cells on IR700DX-6T-PDT.

  • 1/16

    Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Mar 1;12(3):e008054. [Abstract]

    Customer Validation
     Ac-DEVD-CHO (100 µM; 4 h), a specific inhibitor of CASP3, attenuated the release of LDH in CT26 and HCT116 cells on IR700DX-6T-PDT.

  • 1/16

    Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Mar 1;12(3):e008054. [Abstract]

    Customer Validation
     Ac-DEVD-CHO (100 µM; 4 h) markedly reduced the number of swollen pyroptotic cells in CT26 and HCT116 cells on IR700DX-6T-PDT. Red arrows represent pyroptotic cells.

  • 1/16

    Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 Nov 1:520:143-159. [Abstract]

    Customer Validation
     Ac-DEVD-CHO (DEVD) (10 mM) decreased the pyroptosis ratio and the formation of pyroptotic-like cells in Eca109 and Ec9706 cells.

  • 1/16

    Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: Apoptosis. 2019 Oct;24(9-10):703-717. [Abstract]

    Customer Validation
     BMDMs were first primed with LPS (500 ng/ml) for 4 h, pre-treated with or without MCC950 (1 μM) and caspase-3 inhibitor Ac-DEVD-CHO (DEVD) for 1 h and followed by stimulation with ATP (5 mM) in the presence or absence of MCC950. The cell lysates are collected and western blotting is performed to assess the expression levels of indicated proteins.

  • Ac-DEVD-CHO TFA