Acyclovir monophosphate
Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity.
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- CAS 番号: 66341-16-0
- 分子式: C8H12N5O6P
- 分子量:305.18
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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DNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
20 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
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Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
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[PMID: 22954898] |
| Vero | EC50 |
41 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
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Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
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[PMID: 22954898] |
| Vero | CC50 |
>2000 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
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Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
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[PMID: 22954898] |
化学情報
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CAS 番号 66341-16-0
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分子量 305.18
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分子式 C8H12N5O6P
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SMILES
O=C1N=C(NC2=C1N=CN2COCCOP(O)(O)=O)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Acyclovir monophosphate 関連分類
HY-17422B 関連分類
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