AS1604498
AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 361465-74-9
- 分子式: C19H17N3O2
- 分子量:319.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
AS1604498 (0.032-10 μM; 48 h) inhibits THP-1 human leukemia cell growth with an IC50 of 198 nM, and this effect is reversed by 10 mM Nicotinamide (HY-B0150)[1].
AS1604498 (0.032-10 μM; 48 h) inhibits K562 human chronic myelogenous leukemia cell growth with an IC50 of 673 nM, and this effect is reversed by 10 mM Nicotinamide[1].
AS1604498 (10 μM; 48 h) induces delayed caspase 3/7 activation in THP-1 cells, and this activation is reversed by 10 mM Nicotinamide[1].
AS1604498 (0.001-10 μM; 5 h) reduces intracellular NAD levels in K562 cells in a dose-dependent manner, and this effect is reversed by 10 mM Nicotinamide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 human leukemia cell
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Concentration:0.032, 0.1, 0.32, 1, 3.2, 10 μM
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Incubation Time:48 h
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Result:Dose-dependently inhibited THP-1 cell proliferation, with an IC50 of 198 nM (equivalent to 198 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.
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Cell Line:K562 human chronic myelogenous leukemia cell
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Concentration:0.032, 0.1, 0.32, 1, 3.2, 10 μM
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Incubation Time:48 h
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Result:Dose-dependently inhibited K562 cell proliferation, with an IC50 of 673 nM (equivalent to 673 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.
化学情報
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CAS 番号 361465-74-9
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分子量 319.36
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分子式 C19H17N3O2
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SMILES
O=C(NCCCN1C=NC=C1)C=2OC(C#CC=3C=CC=CC3)=CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AS1604498 関連分類
HY-119159 関連分類
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- AS1604498
- 361465-74-9
- AS 1604498
- AS-1604498
- NAMPT
- Caspase
- Apoptosis
- NAMPT dimer interface pocket
- cancer cells
- K562 human chronic myelogenous leukemia cell
- NAMPT enzyme activity
- caspase 3/7
- human NAMPT
- chronic myelogenous leukemia
- THP-1 human leukemia cell
- intracellular NAD levels
- nicotinamide mononucleotide
- Inhibitor
- inhibitor
- inhibit