BRD2492
Based on 1 Customer Validation
BRD2492 (compound 6d) is a potent, selective HDAC1 and HDAC2 inhibitor with IC50s of 13.2 nM and 77.2 nM, respecrtively. BRD2492 exhibits >100-fold selectivity for HDAC1/2 over selectivity over HDAC3 and HDAC6. BRD2492 inhibits breast cancer cell lines growth with IC50s of 1.01 μM and 11.13 μM for T-47D and MCF-7 cells, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.22%
- CAS 番号: 1821669-43-5
- 分子式: C20H18N4O2
- 分子量:346.38
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Reprogramming Compound Library
HY-L039
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Oxygen Sensing Compound Library
HY-L045
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Liver Cancer Compound Library
HY-L101
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Osteogenesis Compound Library
HY-L131
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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High-Throughput Bioactive Compound Library
HY-L205
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High-Efficiency Gene Editing Compound Library
HY-L244
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Lactylation Compound Library
HY-L249
生物活性
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HDAC1 13.2 nM (IC50) |
HDAC2 77.2 nM (IC50) |
HDAC3 8908 nM (IC50) |
HDAC6 >1000 nM (IC50) |
化学情報
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CAS 番号 1821669-43-5
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性状 Solid
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分子量 346.38
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分子式 C20H18N4O2
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Color White to off-white
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SMILES
O=C(NC1=C(N)C=CC(C2=CC=NC=C2)=C1)C3=CC=C(NC(C)=O)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 31.25 mg/mL (90.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8870 mL | 14.4350 mL | 28.8700 mL | 72.1751 mL |
| 5 mM | 0.5774 mL | 2.8870 mL | 5.7740 mL | 14.4350 mL | |
| 10 mM | 0.2887 mL | 1.4435 mL | 2.8870 mL | 7.2175 mL | |
| 15 mM | 0.1925 mL | 0.9623 mL | 1.9247 mL | 4.8117 mL | |
| 20 mM | 0.1444 mL | 0.7218 mL | 1.4435 mL | 3.6088 mL | |
| 25 mM | 0.1155 mL | 0.5774 mL | 1.1548 mL | 2.8870 mL | |
| 30 mM | 0.0962 mL | 0.4812 mL | 0.9623 mL | 2.4058 mL | |
| 40 mM | 0.0722 mL | 0.3609 mL | 0.7218 mL | 1.8044 mL | |
| 50 mM | 0.0577 mL | 0.2887 mL | 0.5774 mL | 1.4435 mL | |
| 60 mM | 0.0481 mL | 0.2406 mL | 0.4812 mL | 1.2029 mL | |
| 80 mM | 0.0361 mL | 0.1804 mL | 0.3609 mL | 0.9022 mL |
BRD2492 関連分類
HY-124053 関連分類
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