Cudraflavone B
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells.
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- CAS 番号: 19275-49-1
- 分子式: C25H24O6
- 分子量:420.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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NF-κB |
COX-2 |
COX-1 |
TNFRSF1A |
p38 MAP kinase |
ERK |
SIRT1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BTI-TN-5B1-4 | IC50 |
41.6 μM
Compound: 12
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Inhibition of human ACAT2 expressed in Hi5 cells
Inhibition of human ACAT2 expressed in Hi5 cells
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[PMID: 16919944] |
| RAW264.7 | IC50 |
7.4 μg/mL
Compound: 128
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
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[PMID: 31255927] |
| THP-1 | IC50 |
>10 μM
Compound: 7
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Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
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[PMID: 24901948] |
化学情報
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CAS 番号 19275-49-1
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分子量 420.45
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分子式 C25H24O6
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SMILES
O=C1C2=C(C3=C(C=C2OC(C4=C(O)C=C(O)C=C4)=C1C/C=C(C)\C)OC(C)(C)C=C3)O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Hošek J, et al. Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro. J Nat Prod. 2011 Apr 25;74(4):614-9. [Content Brief]
[2]. Lee HJ, et al. Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway. Planta Med. 2013 Sep;79(14):1298-306. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cudraflavone B 関連分類
HY-N10009 関連分類
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