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製品番号: HY-N21802

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Dendrocandin U

Dendrocandin U is a bibenzyl compound found in Dendrobium officinale that exhibits anti-inflammatory activity and α-glucosidase inhibitory effect (IC₅₀ = 9.46 mM). Dendrocandin U inhibits the expression of TLR4 and MyD88 in the TLR4/MyD88/NF-kB pathway, suppresses the phosphorylation of NF-kB p65 and I-kBα, and blocks the nuclear translocation of NF-kB p65. Dendrocandin U inhibits M1 polarization, NO secretion, and TNF-α release in alveolar macrophages, and reduces inflammatory morphological changes in macrophages. Dendrocandin U promotes neurite outgrowth in PC12 cells. Dendrocandin U can be used for research on inflammation-related diseases and type 2 diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1922084-93-2
分子式: C₂₆H₂₈O₈
分子量:468.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dendrocandin U 構造式

CAS 番号: 1922084-93-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]

NF-κB

TLR4

iNOS

α‑glucosidase

TNF-α

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

NO Synthase アイソフォーム固有の製品をすべて表示 :

TNF Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

Dendrocandin U (compound 1) (0.01-80 μM; 24 h) shows no cytotoxicity against MH-S cells at concentrations below 20 μM^[1].
Dendrocandin U (0.01-20 μM; 2 h pre-incubation) inhibits NO secretion in LPS/IFN-γ-stimulated MH-S cells^[1].
Dendrocandin U (5-20 μM; 2 h pre-incubation) inhibits TNF-α release in LPS/IFN-γ-stimulated MH-S cells at 10 μM^[1].
Dendrocandin U (20 μM; 2 h pre-incubation) attenuates M1-like morphological changes in LPS/IFN-γ-stimulated MH-S cells; inhibits the TLR4/MyD88/NF-κB signaling pathway and nuclear translocation of p-NF-κB p65 in stimulated MH-S cells^[1].
Dendrocandin U (10-20 μM; 2 h pre-incubation) inhibits the expression of M1 markers CD86 and iNOS in stimulated MH-S cells^[1].
Dendrocandin U (compound 11) is a weak α-glucosidase inhibitor with an IC₅₀ of 9.46 mM^[2].
Dendrocandin U (compound 2) (10 μM; 72 h) shows weak neurite outgrowth-promoting activity in PC12 cells, with a differentiation rate of 9.46%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MH-S alveolar macrophages
Concentration:

0.01, 0.1, 1, 5, 10, 20, 40, 80 μM
Incubation Time:

24 h
Result:

Did not exhibit obvious cytotoxicity at doses below 20 μM.

ELISA Assay^[1]

Cell Line:

MH-S alveolar macrophages
Concentration:

5, 10, 20 μM
Incubation Time:

2 h (pre-incubation); 24 h (stimulated with LPS (1 μg/mL) + IFN-γ (20 ng/mL))
Result:

Inhibited the release of TNF-α at 10 μM.

Immunofluorescence^[1]

Cell Line:

MH-S alveolar macrophages
Concentration:

0, 20 μM
Incubation Time:

2 h (pre-incubation); 6 h (stimulated with LPS (1 μg/mL) + IFN-γ (20 ng/mL))
Result:

Decreased the number of pseudopodia and spines on the cell surface, indicating it alleviates the inflammatory morphological changes induced by LPS and IFN-γ.

Western Blot Analysis^[1]

Cell Line:

MH-S alveolar macrophages
Concentration:

0, 10, 20 μM
Incubation Time:

2 h (pre-treatment); 24 h (stimulated with LPS (1 μg/mL) + IFN-γ (20 ng/mL))
Result:

Inhibited the expression of iNOS at 10 μM and 20 μM.

Western Blot Analysis^[1]

Cell Line:

MH-S alveolar macrophages
Concentration:

0, 20 μM
Incubation Time:

2 h (pre-treatment); 24 h (stimulated with LPS (1 μg/mL) + IFN-γ (20 ng/mL))
Result:

Significantly inhibited the expression of TLR4 (P <0.05), MyD88 (P<0.01), p-I-κBα (P<0.05), and p-NF-κB p65 (P < 0.01) at 20 μM.\nDecreased the nuclear p-NF-κB p65 (Ser536) protein level (P < 0.05), while the expression of p-NF-κB p65 (Ser536) in the cytoplasm was not affected (P > 0.05).

Immunofluorescence^[1]

Cell Line:

MH-S alveolar macrophages
Concentration:

0, 20 μM
Incubation Time:

2 h (pre-incubation); 2 h (stimulated with LPS (1 μg/mL) + IFN-γ (20 ng/mL))
Result:

Decreased the fluorescence intensity of nuclear p-NF-κB p65 (Ser536).

Related Protocols :

化学情報

CAS 番号 1922084-93-2
分子量 468.50
分子式 C₂₆H₂₈O₈
SMILES

C(O)[C@H]1[C@@H](OC=2C(O1)=C(OC)C=C(CCC3=CC=C(O)C=C3)C2)C4=CC(OC)=C(O)C(OC)=C4
Structure Classification
- Phenols
- Polyphenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Piao X M, et al. Dendrocandin U from Dendrobium officinale Kimura et Migo Inhibits M1 Polarization in Alveolar Macrophage by Suppressing NF‑κB Signaling Pathway. Chemistry & Biodiversity, 2023, 20(11): e202300999.

[2]. Chu C, et al. Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis. Phytochemistry Letters, 2019, 31: 47-52.

[3]. Yang L, et al. Two new dendrocandins with neurite outgrowth-promoting activity from Dendrobium officinale. Journal of Asian natural products research. 2015;17(2):125-31.

Calculators

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分子量分子量

希釈計算機

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体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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Dendrocandin U

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

NO Synthase アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC₅₀ & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Dendrocandin U

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

NO Synthase アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Dendrocandin U 関連分類

HY-N21802 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target