Destruxin B
Based on 1 publication(s) in Google Scholar
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.35%
- CAS 番号: 2503-26-6
- 分子式: C32H55N5O7
- 分子量:621.81
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Destruxin B
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生物活性
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Bcl-2 |
Caspase-3 |
Destruxin B (1-30 μM; 48 hours) inhibits cell proliferation of H1299 cells and A549 cells, with IC50s of 4.1?μM and 4.9?μM, respectively[1].
Activation of mitochondria-dependent caspase cascade plays an important role in Destruxin B (1-30 μM; 48 hours) induced apoptotic cell death in A549 cells[1].
Destruxin B (1.25-20.00 μM; 72 hours) treatment significantly inhibits HT-29 human colorectal cancer cells viability in time- and dose-dependent manners[2].
Destruxin B (10 or 20?μM; 12 and 24 hours) treatment markedly increases levels of the proapoptotic protein PUMA and reduces levels of antiapoptotic proteins Mcl-1 of A549 cells in a concentration- and time-dependent manner [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H1299 cells
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Concentration:1, 5, 10, 20, 30 μM
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Incubation Time:48 hours
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Result:Inhibited H1299 cells proliferation of H1299 cells with an IC50 of 4.1 μM.
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Cell Line:Lung adenocarcinoma A549 cells
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Concentration:1, 5, 10, 20, 30 μM
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Incubation Time:48 hours
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Result:Induces caspase-dependent Lung adenocarcinoma A549 cells death.
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Cell Line:HT-29 human colorectal cancer cells
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Concentration:1.25, 2.50, 5.00, 10.00 and 20.00 μM
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Incubation Time:72 hours
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Result:The IC50s at 24 h, 48 h and 72h were determined as 14.97, 2.00 and 0.67 μM, respectively.
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Cell Line:A549 cells
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Concentration:10 or 20 μM
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Incubation Time:12 and 24 hours
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Result:Regulates Mcl-1 and PUMA.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic female nude mice (BALB/cAnN.Cg-Foxn1nu/CrlNarl), approximately 4-5 weeks old on arrival[2]
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Dosage:Low dose (0.6 mg/kg), medium dose (3 mg/kg), high dose (15 mg/kg)
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Administration:Injection; daily; for 6 weeks
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Result:Low dose, medium dose and high dose indicated a reduction of 23.9%, 33.4% and 55.8% in mean tumor size, respectively.
化学情報
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CAS 番号 2503-26-6
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性状 Solid
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分子量 621.81
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分子式 C32H55N5O7
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Color White to off-white
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SMILES
O=C(N[C@]([C@@H](C)CC)(C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H](C)C(NCC1)=O)=O)=O)[C@@](CCC2)(C)N2C([C@@H](CC(C)C)OC1=O)=O
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Structure Classification
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Initial Source
Metarhizium anisopliae
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Neotrop Entomol
Biomass and Extracts of Metarhizium robertsii MT008 as Potential Biopesticides for Controlling the Fruit Fly Anastrepha obliqua. [Abstract]2025 Nov 27;54(1):118. PMID: 41307647
溶剤 & 溶解度
Ethanol : 12.5 mg/mL (20.10 mM; Need ultrasonic and warming)
DMSO : ≥ 10 mg/mL (16.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (285 KB)
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SDS (393 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.6082 mL | 8.0410 mL | 16.0821 mL | 40.2052 mL |
| 5 mM | 0.3216 mL | 1.6082 mL | 3.2164 mL | 8.0410 mL | |
| 10 mM | 0.1608 mL | 0.8041 mL | 1.6082 mL | 4.0205 mL | |
| 15 mM | 0.1072 mL | 0.5361 mL | 1.0721 mL | 2.6803 mL | |
| Ethanol | 20 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 2.0103 mL |
Destruxin B 関連分類
HY-N6690 関連分類
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