Destruxin B
Based on 1 publication(s) in Google Scholar
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo.
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- 純度: 99.35%
- CAS 番号: 2503-26-6
- 分子式: C32H55N5O7
- 分子量:621.81
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Destruxin B
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生物活性
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Bcl-2 |
Caspase-3 |
Destruxin B (1-30 μM; 48 hours) inhibits cell proliferation of H1299 cells and A549 cells, with IC50s of 4.1?μM and 4.9?μM, respectively[1].
Activation of mitochondria-dependent caspase cascade plays an important role in Destruxin B (1-30 μM; 48 hours) induced apoptotic cell death in A549 cells[1].
Destruxin B (1.25-20.00 μM; 72 hours) treatment significantly inhibits HT-29 human colorectal cancer cells viability in time- and dose-dependent manners[2].
Destruxin B (10 or 20?μM; 12 and 24 hours) treatment markedly increases levels of the proapoptotic protein PUMA and reduces levels of antiapoptotic proteins Mcl-1 of A549 cells in a concentration- and time-dependent manner [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H1299 cells
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Concentration:1, 5, 10, 20, 30 μM
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Incubation Time:48 hours
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Result:Inhibited H1299 cells proliferation of H1299 cells with an IC50 of 4.1 μM.
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Cell Line:Lung adenocarcinoma A549 cells
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Concentration:1, 5, 10, 20, 30 μM
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Incubation Time:48 hours
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Result:Induces caspase-dependent Lung adenocarcinoma A549 cells death.
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Cell Line:HT-29 human colorectal cancer cells
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Concentration:1.25, 2.50, 5.00, 10.00 and 20.00 μM
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Incubation Time:72 hours
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Result:The IC50s at 24 h, 48 h and 72h were determined as 14.97, 2.00 and 0.67 μM, respectively.
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Cell Line:A549 cells
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Concentration:10 or 20 μM
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Incubation Time:12 and 24 hours
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Result:Regulates Mcl-1 and PUMA.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic female nude mice (BALB/cAnN.Cg-Foxn1nu/CrlNarl), approximately 4-5 weeks old on arrival[2]
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Dosage:Low dose (0.6 mg/kg), medium dose (3 mg/kg), high dose (15 mg/kg)
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Administration:Injection; daily; for 6 weeks
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Result:Low dose, medium dose and high dose indicated a reduction of 23.9%, 33.4% and 55.8% in mean tumor size, respectively.
化学情報
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CAS 番号 2503-26-6
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性状 Solid
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分子量 621.81
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分子式 C32H55N5O7
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Color White to off-white
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SMILES
O=C(N[C@]([C@@H](C)CC)(C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H](C)C(NCC1)=O)=O)=O)[C@@](CCC2)(C)N2C([C@@H](CC(C)C)OC1=O)=O
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Structure Classification
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Initial Source
Metarhizium anisopliae
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Neotrop Entomol
Biomass and Extracts of Metarhizium robertsii MT008 as Potential Biopesticides for Controlling the Fruit Fly Anastrepha obliqua. [Abstract]2025 Nov 27;54(1):118. PMID: 41307647
溶剤 & 溶解度
Ethanol : 12.5 mg/mL (20.10 mM; Need ultrasonic and warming)
DMSO : ≥ 10 mg/mL (16.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.6082 mL | 8.0410 mL | 16.0821 mL | 40.2052 mL |
| 5 mM | 0.3216 mL | 1.6082 mL | 3.2164 mL | 8.0410 mL | |
| 10 mM | 0.1608 mL | 0.8041 mL | 1.6082 mL | 4.0205 mL | |
| 15 mM | 0.1072 mL | 0.5361 mL | 1.0721 mL | 2.6803 mL | |
| Ethanol | 20 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 2.0103 mL |
Destruxin B 関連分類
HY-N6690 関連分類
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