eALM1192
eALM1192 is a selective mTOR kinase inhibitor (IC50 = 2.3 nM) that also inhibits DNA-PK (IC50 = 84 nM), PI3Kα, and PKN3, with 37-fold selectivity for mTOR over DNA-PK. eALM1192 exhibits antiproliferative activity against cancer cell lines and colorectal cancer cell lines. eALM1192 can be used for colorectal cancer research.
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- CAS 番号: 3134761-90-0
- 分子式: C23H23N7O3
- 分子量:445.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
mTOR 2.3 nM (IC50) |
DNA-PK 84 nM (IC50) |
PI3Kα |
PKN3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SW48 | EC50 |
5.6 nM
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Antiproliferative activity against human SW48 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
Antiproliferative activity against human SW48 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
|
D6MD00572A |
| HCT-116 | EC50 |
49 nM
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Antiproliferative activity against human HCT116 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
Antiproliferative activity against human HCT116 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
|
D6MD00572A |
| SW480 | EC50 |
63 nM
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Antiproliferative activity against human SW480 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
Antiproliferative activity against human SW480 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
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D6MD00572A |
体外実験
2w (eALM1192) (1-10000 nM; 5 days) exhibits potent low-nanomolar antiproliferative activity across SW48, HCT116 and SW480 colorectal cancer cell lines[1].
eALM1192 (1 μM) acts as a highly selective inhibitor, demonstrating potent activity (determined as residual activity at 1 μM) primarily against MTOR, DNAPK, and PIK3CA/PIK3R1.
2w (eALM1192) (0.09-3000 nM) is a potent mTOR inhibitor with an IC50 of 2.3 nM and 37-fold selectivity over DNA-PK[1].
2w (eALM1192) (1 µM; 0-45 min) demonstrates excellent metabolic stability with a half-life of 109 min in human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3134761-90-0
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分子量 445.47
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分子式 C23H23N7O3
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SMILES
O=C(N1CCC(CN2C=C(C3=CC=C(OC(N)=N4)C4=C3)C5=C(N)N=CN=C52)CC1)OCC#C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
eALM1192 関連分類
HY-189486 関連分類
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