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製品番号: HY-N21740

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Furohyperforin

Furohyperforin is a natural product isolated from Hypericum perforatum L., possessing neuroprotective and antidepressant activities. Furohyperforin acts as an NLRP3 inflammasome inhibitor and also exhibits inhibitory effects on recombinant CYP3A4. Furohyperforin exerts neuroprotective effects against corticosterone-induced neuronal damage. Furohyperforin inhibits the NLRP3 inflammasome cascade and its downstream IL‑1β and GSDMD signaling pathways, and also reduces serum corticosterone levels in mice, regulating HPA axis function. Furohyperforin is applicable for depression-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 219793-20-1
分子式: C₃₅H₅₂O₅
分子量:552.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Furohyperforin 構造式

CAS 番号: 219793-20-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]

CYP3A4

NLRP3

IL-1β

Cytochrome P450 アイソフォーム固有の製品をすべて表示 :

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

体外実験

OthersInflammasomePyroptosisInnate Immunity

Others

Furohyperforin inhibits recombinant CYP3A4 enzyme activity with an IC₅₀ of 1.3 μM^[1].
Furohyperforin (compound 7) (10 μM) protects SH-SY5Y cells against CORT-induced injury^[2].
Furohyperforin (10-50 μM; 24 h) inhibits LPS-induced BV2 cell injury and shows no cytotoxicity to BV2 cells^[2].
Furohyperforin exhibits weak inhibitory activity on synaptosomal serotonin uptake in rat brain synaptosomes^[4].
Furohyperforin (compound 10) (10 μg/mL; 2 h pretreatment before KCl injury induction) shows no activity against KCl-induced SH-SY5Y cell injury and no activity against CORT-induced PC12 cell injury, indicating that the β-orientation of the substituent is crucial for neuroprotective activity^[5].

Inflammasome

Pyroptosis

Innate Immunity

Furohyperforin (5-20 μM; 30 min) inhibits NLRP3 inflammasome activation in LPS/nigericin-stimulated BV2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

BV2
Concentration:

5, 10, 20 μM
Incubation Time:

30 min
Result:

Significantly inhibited the release of NLRP3, ASC, caspase-1, and pro-caspase-1.
Reduced the expression levels of IL-1β, pro-IL-1β, and GSDMD.

Cell Cytotoxicity Assay^[2]

Cell Line:

BV2
Concentration:

10, 20 μM
10, 20, 50 μM
Incubation Time:

24 h
Result:

Inhibited LPS-induced BV2 cell injury and showed no cytotoxicity to BV2 cells.

Cell Viability Assay^[5]

Cell Line:

SH-SY5Y, PC12
Concentration:

10 μg/mL
Incubation Time:

2 h pre-treatment prior to 24 h KCl or CORT injury induction
Result:

Was inactive in the KCl-induced SH-SY5Y cell injury model.
Was inactive in the CORT-induced PC12 cell injury model.

体内実験

Furohyperforin (compound 7) (1.25-5 mg/kg) exhibits significant antidepressant activity in mice, comparable to Fluoxetine (HY-B0102) and Neurostan, and reduces serum CORT levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Pyroptosis Solutions

化学情報

CAS 番号 219793-20-1
分子量 552.78
分子式 C₃₅H₅₂O₅
SMILES

O=C1[C@@]23C(O[C@@H](C3)C(C)(O)C)=C(C([C@@]1([C@@](C)([C@H](C2)C/C=C(C)\C)CC/C=C(C)/C)C(C(C)C)=O)=O)C/C=C(C)\C
Structure Classification
- Others
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Lee JY, et al. Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry. 2006 Dec;67(23):2550-60.

[2]. Pan XG, et al. NOD-like receptor protein 3 inhibitors in St. John's wort and their potential antidepressant effects. International journal of biological macromolecules. 2025 May;306(Pt 4):141721.

[3]. Galeotti N, et al. St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. Biochemical pharmacology. 2010 May 01;79(9):1327-36.

[4]. Jensen AG, et al. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life sciences. 2001 Feb 23;68(14):1593-605.

[5]. Zeng YR, et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum. Journal of Asian natural products research. 2021 Jan 2;23(1):73-81.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Furohyperforin

Cytochrome P450 アイソフォーム固有の製品をすべて表示

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示