CDK3 - cyclin dependent kinase 3 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 1018

About CDK3

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,000,855-76,005,998 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 26 paralogues. Ubiquitous expression in skin (RPKM 8.9), small intestine (RPKM 6.9) and 25 other tissues.

Summary

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

CDK3 Products (1)

mRNA Protein Name
NM_001258.4 NP_001249.1 cyclin-dependent kinase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
9840943 GOA
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
24550317 GOA
involved in G0 to G1 transition IDA
IDA: Inferred from direct assay
15084261 GOA
involved in negative regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
25344755 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
15084261 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (4 - 286)

  • 0
  • 100
  • 200
  • 305 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 3

  • cell division protein kinase 3

CDK3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CDK3 Q00526 CCNI Homo sapiens Q14094
Validated Y2H
32296183
Intra
CDK3 Q00526 CCNI Homo sapiens Q14094
Y2H Array
32296183
Intra
CDK3 Q00526 CCNI Homo sapiens Q14094
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra
CDK3 Q00526 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra
CDK3 Q00526 SPDYE4 Homo sapiens A6NLX3
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 SPDYE4 Homo sapiens A6NLX3
Y2H Array
32296183
Intra
CDK3 Q00526 a0a384nq31_human Homo sapiens A0A384NQ31
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 a0a384nq31_human Homo sapiens A0A384NQ31
Y2H Array
32296183
Intra
CDK3 Q00526 OR2G6 Homo sapiens Q5TZ20
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 OR2G6 Homo sapiens Q5TZ20
Validated Y2H
32296183
Intra
CDK3 Q00526 OR2G6 Homo sapiens Q5TZ20
Y2H Array
32296183
Intra
CDK3 Q00526 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
CDK3 Q00526 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CDK3 Q00526 PAX8 Homo sapiens Q06710
Validated Y2H
32296183
Intra
CDK3 Q00526 PAX8 Homo sapiens Q06710
Y2H Array
32296183
Intra
CDK3 Q00526 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 LHX4 Homo sapiens Q969G2
Validated Y2H
32296183
Intra
CDK3 Q00526 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
CDK3 Q00526 PAX5 Homo sapiens Q02548
Validated Y2H
32296183
Intra
CDK3 Q00526 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra
CDK3 Q00526 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
28514442
Intra
CDK3 Q00526 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
Intra
CDK3 Q00526 CCND3 Homo sapiens P30281
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 CCND3 Homo sapiens P30281
Y2H Array
32296183
Intra
CDK3 Q00526 CCNE2 Homo sapiens O96020
Anti Tag CoIP
33961781
Intra
CDK3 Q00526 CCNE2 Homo sapiens O96020
Anti Tag CoIP
28514442
Intra
CDK3 Q00526 CDKN1A Homo sapiens P38936
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 CDKN1A Homo sapiens P38936
Y2H Array
32296183
Intra
CDK3 Q00526 CDKN1A Homo sapiens P38936
Anti Tag CoIP
33961781
Intra
CDK3 Q00526 CDKN1A Homo sapiens P38936
TAP
23602568
Intra
CDK3 Q00526 CDKN1A Homo sapiens P38936
Anti Tag CoIP
28514442
Intra
CDK3 Q00526 CCNC Homo sapiens P24863
Y2H Array
32296183
Intra
CDK3 Q00526 CCNC Homo sapiens P24863
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 CKS1B Homo sapiens P61024
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 CKS1B Homo sapiens P61024
TAP
23602568
Intra
CDK3 Q00526 CKS1B Homo sapiens P61024
Anti Tag CoIP
33961781
Intra
CDK3 Q00526 CKS1B Homo sapiens P61024
Y2H Array
32296183
Intra
CDK3 Q00526 NELFA Homo sapiens Q9H3P2
Y2H Array
32296183
Intra
CDK3 Q00526 NELFA Homo sapiens Q9H3P2
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 NELFA Homo sapiens Q9H3P2
Validated Y2H
32296183
Intra
CDK3 Q00526 CKS2 Homo sapiens P33552
Anti Tag CoIP
33961781
Intra
CDK3 Q00526 CKS2 Homo sapiens P33552
Anti Tag CoIP
28514442
Intra
CDK3 Q00526 CKS2 Homo sapiens P33552
Y2H Array
32296183
Intra
CDK3 Q00526 CKS2 Homo sapiens P33552
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 RACGAP1 Homo sapiens Q9H0H5
Y2H Array
32296183
Intra
CDK3 Q00526 RACGAP1 Homo sapiens Q9H0H5
Validated Y2H
32296183
Intra
CDK3 Q00526 RACGAP1 Homo sapiens Q9H0H5
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 CCNH Homo sapiens P51946
Y2H Array
32296183
Intra
CDK3 Q00526 CCNH Homo sapiens P51946
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
CDK3 Q00526 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra
CDK3 Q00526 FOXP2 Homo sapiens O15409
Y2H Prey Pooling
32296183
Intra
CDK3 Q00526 FOXP2 Homo sapiens O15409
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CDK3 抗体

製品番号 製品名 アプリケーション 反応性
HY-P80797 Phospho-CDK1/2/3 (Thr14) Antibody (YA218) WB, IP Human, Hamster
HY-P80797A Phospho-CDK1/2/3 (Thr14) Antibody (YA218)(PBS only) WB, IP Human, Hamster

関連疾患

Diseases Alias
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-B1165 Cyproheptadine (hydrochloride sesquihydrate) 99.74% Unkown

Clinical Phase

Bioactive Molecules (9)
製品番号 製品名 製品効果
純度 Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Phase 2
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Phase 2
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-137443 Ipivivint Inhibitor 99.95% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.09% Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-N9561 Vanicoside B Inhibitor 99.82% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader 97.22% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus CDK3 VGNC VGNC:107052
Mus musculus CDK3 MGD MGI:1916931
Bos taurus CDK3 VGNC VGNC:55794
Canis familiaris CDK3 VGNC VGNC:51938
Others CDK3 NCBI