GFB-12811
Based on 1 publication(s) in Google Scholar
GFB-12811 is a high selective CDK5 inhibitor with an IC50 of 2.3 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.04%
- CAS 番号: 2775311-17-4
- 分子式: C22H23F4N5O
- 分子量:449.44
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 GFB-12811
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生物活性
製品説明
IC50 & Target
[1]|
Cdk5/p25 2.3 nM (IC50) |
CDK2/CycA 211 nM (IC50) |
CDK7/Cyclin H/MAT1 718 nM (IC50) |
CDK9/CycT1 894 nM (IC50) |
CDK6 3197 nM (IC50) |
体外実験
GFB-12811 exhibits a good metabolic stability and a low clearance in mouse hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2775311-17-4
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性状 Solid
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分子量 449.44
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分子式 C22H23F4N5O
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Color Light yellow to yellow
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SMILES
CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Res Sq
Cyclin-Dependent Kinase 5 Contributes to Bruton's Tyrosine Kinase Inhibitor Resistance via the IRE1α/XBP1 Axis in Mantle Cell Lymphoma. [Abstract]2026 May 8:rs.3.rs-9500406. PMID: 42147166
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (111.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2250 mL | 11.1250 mL | 22.2499 mL | 55.6248 mL |
| 5 mM | 0.4450 mL | 2.2250 mL | 4.4500 mL | 11.1250 mL | |
| 10 mM | 0.2225 mL | 1.1125 mL | 2.2250 mL | 5.5625 mL | |
| 15 mM | 0.1483 mL | 0.7417 mL | 1.4833 mL | 3.7083 mL | |
| 20 mM | 0.1112 mL | 0.5562 mL | 1.1125 mL | 2.7812 mL | |
| 25 mM | 0.0890 mL | 0.4450 mL | 0.8900 mL | 2.2250 mL | |
| 30 mM | 0.0742 mL | 0.3708 mL | 0.7417 mL | 1.8542 mL | |
| 40 mM | 0.0556 mL | 0.2781 mL | 0.5562 mL | 1.3906 mL | |
| 50 mM | 0.0445 mL | 0.2225 mL | 0.4450 mL | 1.1125 mL | |
| 60 mM | 0.0371 mL | 0.1854 mL | 0.3708 mL | 0.9271 mL | |
| 80 mM | 0.0278 mL | 0.1391 mL | 0.2781 mL | 0.6953 mL | |
| 100 mM | 0.0222 mL | 0.1112 mL | 0.2225 mL | 0.5562 mL |
GFB-12811 関連分類
HY-144117 関連分類
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