IRF5-CPP5
Based on 1 Customer Validation
IRF5-CPP5 is a cytosolic peptide that selectively targeting human IRF5 wirh a Kd of 0.53 μM. IRF5-CPP5 disrupts IRF5 homodimerization and inhibits its nuclear translocation without altering IRF5 phosphorylation levels. IRF5-CPP5 inhibits proinflammatory cytokine (IL-6, IL-1β, TNF-α) production. IRF5-CPP5 can be used for the research of systemic lupus erythematosus.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.23%
- CAS 番号: 1601299-92-6
- 分子式: C160H245N37O36S
- 分子量:3294.95
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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IL-6 |
IL-1β |
IRF5-CPP5 binds to recombinant monomeric IRF5 (222 to 425) with a submicromolar Kd of 0.53 μM[1].
IRF5-CPP5 inhibits homodimerization of recombinant full-length IRF5 S430D and WT variants with IC50 values of 15.3 and 15.4 μM[1].
IRF5-CPP5 (1-10 μM; 1 h) dose-dependently inhibits R848 (HY-13740 -induced endogenous IRF5 homodimerization in THP-1 human monocytic cells[1].
IRF5-CPP5 (5 μM; 30-60 min) penetrates and colocalizes with endogenous IRF5 in human primary CD19+ B cells, CD14+ monocytes, and BDCA2+ CD123+ pDCs[1].
IRF5-CPP5 (0.62-50 μM; 30 min) concentration-dependently inhibits R848-induced IL12p40 production in human primary PBMCs[1].
IRF5-CPP5 (0.62-16.07 μM) concentration-dependently inhibits R848-induced IRF5 nuclear translocation in human primary CD14+ monocytes and CD19+ B cells[1].
IRF5-CPP5 (3.5-15 μM; 1 h) significantly inhibits LPS(HY-D1056) - and R848-induced proinflammatory cytokine (IL-6, IL-1β, TNF-α) production and transcript expression in human primary MDMs[1].
IRF5-CPP5 (0.62-50 μM) concentration-dependently inhibits CpGA-induced IFNα production in human primary BDCA2+ CD123+ pDCs[1].
IRF5-CPP5 (0.62-16.07 μM; 30 min) concentration-dependently inhibits SLE serum-induced IRF5 and phosphorylated IRF5 (pSer462) nuclear translocation in human primary CD14+ monocytes, CD19+ B cells, and BDCA2+ CD123+ pDCs, without altering total pIRF5 levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 human monocytic cells
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Concentration:1, 10 μM
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Incubation Time:1 h
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Result:Reduced (IRF5)2 levels.
化学情報
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CAS 番号 1601299-92-6
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性状 Solid
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分子量 3294.95
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分子式 C160H245N37O36S
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Color White to off-white
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配列
Met-Ala-Asn-Leu-Gly-Tyr-Trp-Leu-Leu-Ala-Leu-Phe-Val-Thr-Tyr-Trp-Thr-Asp-Leu-Gly-Leu-Val-Lys-Lys-Arg-Pro-Lys-Pro
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シーケンスの短縮
MANLGYWLLALFVTYWTDLGLVKKRPKP
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 50 mg/mL (15.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3035 mL | 1.5175 mL | 3.0349 mL | 7.5874 mL |
| 5 mM | 0.0607 mL | 0.3035 mL | 0.6070 mL | 1.5175 mL | |
| 10 mM | 0.0303 mL | 0.1517 mL | 0.3035 mL | 0.7587 mL | |
| 15 mM | 0.0202 mL | 0.1012 mL | 0.2023 mL | 0.5058 mL |
IRF5-CPP5 関連分類
HY-P11072 関連分類
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