KTT-1
KTT-1 is a kinetically selective and orally active HDAC2 inhibitor. KTT-1 exhibits high HDAC2-selectivity over HDAC1. KTT-1 inhibits osteoclast differentiation at an early stage by downregulating c-Fos expression. KTT-1 effectively suppresses arthritis symptoms in the collagen-induced arthritis (CIA) mouse model. KTT-1 can be used for the research of rheumatoid arthritis and neurodegenerative diseases.
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- CAS 番号: 2397562-26-2
- 分子式: C26H21N5O4S
- 分子量:499.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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HDAC2 |
KTT-1 (25-200 nM; Bone Marrow-Derived Macrophages (BM cells)) reduces the number of osteoclasts and the expression of key osteoclast differentiation genes[1].
KTT-1 (25-100 nM; Bone Marrow-Derived Macrophages (BMDMs)) reduces IL-1β and IL-6 production without affecting TNF-α production[1].
KTT-1 (Day 6, Day 8, Day 10; Bone Marrow-Derived Macrophages (BM cells)) alters gene expression and arrests osteoclast differentiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
KTT-1 (0.03 mg/mL (6 mg/kg/day); drinking water; 22 days) alleviates arthritis severity in CAIA model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1JJmsSlc (male, 6-7 weeks old, collagen-induced arthritis (CIA) model)[1]
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Dosage:0.03 mg/mL (6 mg/kg/day)
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Administration:Drinking water; 10 consecutive days
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Result:Arthritis severity was significantly attenuated, as evidenced by reduced clinical scores and histological scores.
Showed markedly reduced synovial inflammation and immune cell infiltration, with preservation of normal joint architecture.
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Animal Model:DBA/1JJmsSlc (male, 6-7 weeks old, collagen antibody-induced arthritis (CAIA) model)[1]
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Dosage:0.03 mg/mL (6 mg/kg/day)
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Administration:Drinking water; 22 days
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Result:Arthritis severity was significantly alleviated, as indicated by reduced clinical scores and improved body weight gain.
化学情報
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CAS 番号 2397562-26-2
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分子量 499.54
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分子式 C26H21N5O4S
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SMILES
O=C(NC1=CC(C2=CC=CO2)=CC=C1N)C(C=C3)=CC=C3C(N=N4)=CN4CS(=O)(C5=CC=CC=C5)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KTT-1 関連分類
HY-179216 関連分類
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