Merulidial
Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 68053-32-7
- 分子式: C15H20O3
- 分子量:248.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Merulidial (Compound 1) (25 mg/mL, 3-5 days)significantly prevents the hyphal growth, with the clear zones from the edge of the well of 4-7 mm (C. cucumerinum) and 15-19 mm (H. annosum), respectively[1].
Merulidial (6.3-25 μg/mL, 24 h) strongly inhibits germination of H. annosum spores at both 12.5 and 25 μg/mL with delay germination at 6.3 ug/mL, and shows a weak effect on C. cucumerinum spore germination, delaying by at least 48 h[1].
Merulidial (50 μg/plate) has a mutagenic activity in the Ames' Salmonella assay for mutant strains TA98, TA2637 and TA100 with mutagenic rate of 0.62、0.28 and 1.5 revertants/nmol[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 68053-32-7
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分子量 248.32
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分子式 C15H20O3
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SMILES
O=C[C@@]12[C@@](C1)([C@H]([C@@]3([H])C(CC(C)(C3)C)=C2C=O)O)C
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別名
(-)-Merulidial
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Structure Classification
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Initial Source
Physisporinus sanguinolentus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. 1. Svensson M, et al. Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus. Phytochemistry. 2001 Apr; 56(7):747-51. [Content Brief]
[2]. 2. Quack W, et al. Antibiotics from Basidiomycetes. V merulidial, a new antibiotic from the Basidiomycete Merulius tremellosus Fr. J Antibiot (Tokyo). 1978 Aug; 31(8):737-41. [Content Brief]
[3]. 3. Anke H, et al. Structure-activity relationships for unsaturated dialdehydes. 3. Mutagenic, antimicrobial, cytotoxic, and phytotoxic activities of merulidial derivatives. J Antibiot (Tokyo). 1989 May; 42(5):738-44. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Merulidial 関連分類
HY-N15600 関連分類
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