MS4322 (isomer)
Based on 1 Customer Validation
MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer.
(Pink: PRMT5 ligand (HY-173092); Blue: VHL ligand (HY-112078); Black: linker (HY-124780)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.87%
- CAS 番号: 2601727-80-2
- 分子式: C55H76N10O12S
- 分子量:1101.32
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
(Pink: PRMT5 ligand (HY-173092); Blue: VHL ligand (HY-112078); Black: linker (HY-124780)).
|
VHL |
Cereblon |
MDM2 |
SMYD2 |
SMYD3 |
EHMTI PEP |
SETD7/KMT7 |
PRMT4 |
PRMT8 |
EZH1 |
SETDB1/KMT2G |
SETD8/KMT5A |
PRMT5 |
EZH2 |
SUV39H2/KMT1B |
SETD2/KMT3A |
PRMT1 |
PRMT6 |
DOT1L |
EHMT2/G9a/KMT1C |
NSD2 |
PRMT3 |
PRMT7 |
化学情報
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CAS 番号 2601727-80-2
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性状 Solid
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分子量 1101.32
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分子式 C55H76N10O12S
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Color White to off-white
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SMILES
O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O
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別名
YS43-22 (isomer)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (45.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9080 mL | 4.5400 mL | 9.0800 mL | 22.7000 mL |
| 5 mM | 0.1816 mL | 0.9080 mL | 1.8160 mL | 4.5400 mL | |
| 10 mM | 0.0908 mL | 0.4540 mL | 0.9080 mL | 2.2700 mL | |
| 15 mM | 0.0605 mL | 0.3027 mL | 0.6053 mL | 1.5133 mL | |
| 20 mM | 0.0454 mL | 0.2270 mL | 0.4540 mL | 1.1350 mL | |
| 25 mM | 0.0363 mL | 0.1816 mL | 0.3632 mL | 0.9080 mL | |
| 30 mM | 0.0303 mL | 0.1513 mL | 0.3027 mL | 0.7567 mL | |
| 40 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5675 mL |
MS4322 (isomer) 関連分類
HY-141877B 関連分類
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