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製品番号: HY-117720

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OSU-2S

Name: OSU-2S
Brand: MedChemExpress
SKU: HY-117720
Availability: PreOrder

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1351056-65-9
分子式: C₂₁H₃₇NO₂
分子量:335.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

OSU-2S 構造式

CAS 番号: 1351056-65-9

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

PKCδ

PKC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	4.2 μM Compound: OSU-2S	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 28865276]
Hep 3B2	IC₅₀	2.8 μM Compound: OSU-2S	Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay	[PMID: 28865276]
HepG2	IC₅₀	2.3 μM Compound: OSU-2S	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 28865276]
HT-29	IC₅₀	2.7 μM Compound: OSU-2S	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 28865276]

体外実験

OSU-2S (1.25, 2.5 µM; 48 h) decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201) (2.5, 5 µM)^[1].
OSU-2S/Sorafenib (1.25, 2.5 µM; 8 h) combinantion inhibits cell proliferative and migration^[1].
OSU-2S (0, 1, 2.5, 5 µM; 0-24 h) decreases the expression of PARP in a dose and time-dependent manner in Hep3B cells^[2].
OSU-2S (5 µM; 12, 24 h) induces apoptosis in Hep3B cells^[2].
OSU-2S (0-10 µM; 1 h) stimulates ROS production in a dose-dependent manner in Hep3B, Huh7, PLC-5 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Hep3B, Huh7, PLC-5, HepG2 cells
Concentration:

0-10 µM
Incubation Time:

48 h
Result:

Showed anti-proliferative effects with IC₅₀s of 2.53, 2.41, 3.96, 1.84 µM for Hep3B, Huh7, PLC-5, HepG2 cells, respectively.

Western Blot Analysis^[1]

Cell Line:

Hep3B cells
Concentration:

1.25, 2.5 µM combinated with sorafenib (2.5, 5 µM)
Incubation Time:

48 h
Result:

Decreased the expression of ERK1/2 phosphorylation, increased the expression of PKCδ (38 kDa) when sorafenib/OSU-2S combination.

体内実験

OSU-2S (5, 10 mg/kg; i.p.; once daily for 42 days) suppresses the tumor growth in mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD2F1 mice (Hep3B tumor xenograft models)^[2]
Dosage:

5, 10 mg/kg
Administration:

I.p.; once daily for 42 days
Result:

Exhibited a higher tumor-suppressive potency, achieving 80% reduction in bioluminescence at the end of treatment.

化学情報

CAS 番号 1351056-65-9
分子量 335.52
分子式 C₂₁H₃₇NO₂
SMILES

CCC[C@@](CCC1=CC=C(OCCCCCC(C)C)C=C1)(N)CO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Int Immunopharmacol

Osthole alleviates neuropathic pain by suppressing astrocytes activation and associated inflammatory responses via the PKCδ/TRPV4 signaling pathway. [Abstract]

2025 Sep 10:165:115453. PMID: 40934539

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Omar HA, et al. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53. Front Pharmacol. 2016 Nov 30;7:463. [Content Brief]

[2]. Omar HA, et al. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011 Jun;53(6):1943-58. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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OSU-2S

1 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献

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OSU-2S

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