Pterosin A
Based on 1 Customer Validation
Pterosin A ((2S)-Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 94.07%
- CAS 番号: 35910-16-8
- 分子式: C15H20O3
- 分子量:248.32
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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GLUT4 |
p-GSK-3 |
Pterosin A (50 μg/mL, 0.5-4 h) enhances glucose uptake and AMPK phosphorylation in muscle cells[1].
Pterosin A (50-150 μg/mL, 0.5-4 h) inhibits PEPCK expression, triggers the phosphorylations of AMPK, ACC, and GSK-3, decreases glycogen synthase phosphorylation, and increases the intracellular glycogen level in liver cells[1].
Pterosin A (10-100 μM, 18 h) inhibits H2O2-induced ROS production in RINm5f β-cells[2].
Pterosin A (10-100 μM, 24 h) reduces lipotoxicity-induced cell death in RINm5f β-cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Liver cells
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Concentration:50 and 150 μg/mL
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Incubation Time:0.5, 1, 2 and 4 h
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Result:Increased p-AMPK and P-ACC and p-GSK3-α/β levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin (HY-13753), high-fat diet-fed and db/db diabetic mice models[1]
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Dosage:10, 30 and 100 mg/kg
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Administration:Orally administration, daily for 4 weeks
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Result:Reversed the increased serum insulin and insulin resistance in dexamethasone-IR mice.
Reversed the reduced muscle GLUT-4 translocation and the increased liver phosphoenolpyruvate carboxyl kinase (PEPCK) expression.
Reversed the decreased phosphorylations of AMP-activated protein kinase (AMPK) and Akt in muscles.
Reversed increased p38 phosphorylation in livers.
化学情報
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CAS 番号 35910-16-8
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性状 Solid
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分子量 248.32
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分子式 C15H20O3
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Color White to off-white
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SMILES
O=C1C(C(C[C@](C)1CO)=CC(C)=C2CCO)=C2C
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別名
(2S)-Pterosin A
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hsu FL, et al. Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes. 2013 Feb;62(2):628-38. [Content Brief]
[2]. Chen CY, et al. Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci. 2015 Jan 22;16(2):2497-516. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pterosin A 関連分類
HY-N7912 関連分類
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