Quercetin-d3
Based on 1 publication(s) in Google Scholar
Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.73%
- CAS 番号: 263711-79-1
- 分子式: C15H7D3O7
- 分子量:305.25
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Quercetin-d3
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生物活性
製品説明
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 263711-79-1
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非標識Cas 117-39-5
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性状 Solid
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分子量 305.25
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分子式 C15H7D3O7
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Color Off-white to yellow
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SMILES
O=C1C(O)=C(C2=C([2H])C(O)=C(O)C([2H])=C2[2H])OC3=CC(O)=CC(O)=C13
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Pharmacol
Several endocannabinoids and amino acids may be biosynthetically converted to catecholamines in vivo. [Abstract]2025 Jul 18:16:1614460. PMID: 40756988
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (327.60 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [Content Brief]
[3]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. [Content Brief]
[4]. Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277. [Content Brief]
[5]. Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2760 mL | 16.3800 mL | 32.7600 mL | 81.9001 mL |
| 5 mM | 0.6552 mL | 3.2760 mL | 6.5520 mL | 16.3800 mL | |
| 10 mM | 0.3276 mL | 1.6380 mL | 3.2760 mL | 8.1900 mL | |
| 15 mM | 0.2184 mL | 1.0920 mL | 2.1840 mL | 5.4600 mL | |
| 20 mM | 0.1638 mL | 0.8190 mL | 1.6380 mL | 4.0950 mL | |
| 25 mM | 0.1310 mL | 0.6552 mL | 1.3104 mL | 3.2760 mL | |
| 30 mM | 0.1092 mL | 0.5460 mL | 1.0920 mL | 2.7300 mL | |
| 40 mM | 0.0819 mL | 0.4095 mL | 0.8190 mL | 2.0475 mL | |
| 50 mM | 0.0655 mL | 0.3276 mL | 0.6552 mL | 1.6380 mL | |
| 60 mM | 0.0546 mL | 0.2730 mL | 0.5460 mL | 1.3650 mL | |
| 80 mM | 0.0410 mL | 0.2048 mL | 0.4095 mL | 1.0238 mL | |
| 100 mM | 0.0328 mL | 0.1638 mL | 0.3276 mL | 0.8190 mL |
Quercetin-d3 関連分類
HY-18085S1 関連分類
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