(rel)-ML-SI3
Based on 1 publication(s) in Google Scholar
(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM).
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- 純度: 98.94%
- CAS 番号: 2108567-79-7
- 分子式: C23H31N3O3S
- 分子量:429.58
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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MedChemExpress（MCE）の使用を引用している文献 (rel)-ML-SI3
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生物活性
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TRPML1 3.1 μM (IC50) |
TRPML2 3.3 μM (EC50) |
TRPML3 28.5 μM (IC50) |
Table: Activation and inhibition of the three subtypes of TRPML by the ML-SI3-type compounds[3]
Product_Names Catalog_No EC50 for activation [μM] IC50 for inhibition [μM] TRPML1 TRPML2 TRPML3 TRPML1 TRPML2 TRPML3 (rel)-ML-SI3 HY-139426A - 3.3±1.5 - 3.1±1.5 - 28.5±15.9 (cis)-ML-SI3 / - 9.4±2.7 29.0±4.1 18.5±1.9 - - (1S,2S)-ML-SI3 HY-134819 - 2.7±1.4 10.8±0.5 5.9±1.7 - - (1R,2R)-ML-SI3 HY-134819A - - - 1.6±0.7 2.3±1.1 12.5±7.6 Mean values ± SD of at least three independent experiments are shown. -: no effect. ML-SI3 HY-139426 The mixtrue of (rel)-ML-SI3 and (cis)-ML-SI3
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2108567-79-7
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性状 Solid
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分子量 429.58
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分子式 C23H31N3O3S
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Color White to off-white
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SMILES
O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O
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別名
trans-ML-SI3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 50 mg/mL (116.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11(1):8313. [Content Brief] [Content Brief]
[2]. Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966. [Content Brief]
[3]. Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117(1):20. [Content Brief] [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3279 mL | 11.6393 mL | 23.2786 mL | 58.1964 mL |
| 5 mM | 0.4656 mL | 2.3279 mL | 4.6557 mL | 11.6393 mL | |
| 10 mM | 0.2328 mL | 1.1639 mL | 2.3279 mL | 5.8196 mL | |
| 15 mM | 0.1552 mL | 0.7760 mL | 1.5519 mL | 3.8798 mL | |
| 20 mM | 0.1164 mL | 0.5820 mL | 1.1639 mL | 2.9098 mL | |
| 25 mM | 0.0931 mL | 0.4656 mL | 0.9311 mL | 2.3279 mL | |
| 30 mM | 0.0776 mL | 0.3880 mL | 0.7760 mL | 1.9399 mL | |
| 40 mM | 0.0582 mL | 0.2910 mL | 0.5820 mL | 1.4549 mL | |
| 50 mM | 0.0466 mL | 0.2328 mL | 0.4656 mL | 1.1639 mL | |
| 60 mM | 0.0388 mL | 0.1940 mL | 0.3880 mL | 0.9699 mL | |
| 80 mM | 0.0291 mL | 0.1455 mL | 0.2910 mL | 0.7275 mL | |
| 100 mM | 0.0233 mL | 0.1164 mL | 0.2328 mL | 0.5820 mL |
(rel)-ML-SI3 関連分類
HY-139426A 関連分類
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