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製品番号: HY-126566

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Trichostatin C

Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer. Trichostatin C induces differentation of Friend leukemic cells. Trichostatin C exhibits antifungal activity.

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CAS 番号: 68676-88-0
分子式: C₂₃H₃₂N₂O₈
分子量:464.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Trichostatin C 構造式

CAS 番号: 68676-88-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer^[1]. Trichostatin C induces differentation of Friend leukemic cells^[2]. Trichostatin C exhibits antifungal activity^[3].

IC₅₀ & Target

HDAC1

HDAC6

HDAC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A2058	IC₅₀	37.3 μM Compound: 3	Cytotoxicity against human A2058 cells assessed as reduction in cell viability Cytotoxicity against human A2058 cells assessed as reduction in cell viability	[PMID: 32005414]
A549	IC₅₀	25.01 μM Compound: 3	Cytotoxicity against human A549 cells assessed as reduction in cell viability Cytotoxicity against human A549 cells assessed as reduction in cell viability	[PMID: 32005414]
HEK293	IC₅₀	>100 μM Compound: 10	Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay	[PMID: 25556102]
HeLa	IC₅₀	>200 μM Compound: 10	Cytotoxicity against human HeLa cells after 96 hrs by MTT assay Cytotoxicity against human HeLa cells after 96 hrs by MTT assay	[PMID: 25556102]
HepG2	EC₅₀	46.02 μM Compound: 10	Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay	[PMID: 25556102]
HepG2	IC₅₀	>200 μM Compound: 10	Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay	[PMID: 25556102]
HepG2	IC₅₀	17.82 μM Compound: 3	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability Cytotoxicity against human HepG2 cells assessed as reduction in cell viability	[PMID: 32005414]
L02	IC₅₀	>200 μM Compound: 10	Cytotoxicity against human LO2 cells after 96 hrs by MTT assay Cytotoxicity against human LO2 cells after 96 hrs by MTT assay	[PMID: 25556102]
MCF7	IC₅₀	18.87 μM Compound: 3	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability Cytotoxicity against human MCF7 cells assessed as reduction in cell viability	[PMID: 32005414]
MIA PaCa-2	IC₅₀	37.88 μM Compound: 3	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability	[PMID: 32005414]
SW480	IC₅₀	72 μM Compound: 5	Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by EZ-Cytox colorimetric assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by EZ-Cytox colorimetric assay	[PMID: 34455777]
U2OS	IC₅₀	>200 μM Compound: 10	Cytotoxicity against human U2OS cells after 96 hrs by MTT assay Cytotoxicity against human U2OS cells after 96 hrs by MTT assay	[PMID: 25556102]
U2OS	IC₅₀	94.9 μM Compound: 5	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by EZ-Cytox colorimetric assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by EZ-Cytox colorimetric assay	[PMID: 34455777]

体外実験

Trichostatin C (0-100 μM) exhibits inhibitory activity against HDAC1 and HDAC6, inhibits proliferations of cancer cells A549, J82 and SK-BR-3, with IC₅₀s of 6.24, 4.16 and 0.6 μM, respectively^[1].
Trichostatin C (0-10 μM) induces apoptosis in cells J82 through activation of caspase 3 and caspase 7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A549, J82 and SK-BR-3
Concentration:

0-100 μM
Incubation Time:

72 h
Result:

Inhibits proliferations of A549, J82 and SK-BR-3.

Western Blot Analysis^[1]

Cell Line:

J82
Concentration:

20-80 μM
Incubation Time:

24 h
Result:

Induced acetylation of α-Tubulin and Histone 3 (markers of HDAC1 and HDAC6 inhibition).

Apoptosis Analysis^[1]

Cell Line:

J-82
Concentration:

0.1-10 μM
Incubation Time:

48 h
Result:

Activated 23.1, 61.7 and 62.3% caspase 3/7 at 0.1 μM, 1 μM and 10 μM.

化学情報

CAS 番号 68676-88-0
分子量 464.51
分子式 C₂₃H₃₂N₂O₈
SMILES

O=C(NO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)/C=C/C(C)=C/[C@@H](C)C(C2=CC=C(N(C)C)C=C2)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Streptomyces sp. RK98-A74
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang C, et al., Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells[J]. Pharmaceuticals, 2024, 17(4): 425.

[2]. Yoshida M, et al., Trichostatin C, a new inducer of differentiation of Friend leukemic cells[J]. Agricultural and biological chemistry, 1985, 49(2): 563-565.

[3]. Tsuji N, et al., a glucopyranosyl hydroxamate. J Antibiot (Tokyo). 1978 Oct;31(10):939-44. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Trichostatin C

HDAC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Trichostatin C 関連分類

HY-126566 関連分類