Cat. No.: HY-N9551

Eriodictyol chalcone

Name: Eriodictyol chalcone
Brand: MedChemExpress
SKU: HY-N9551
Price: 240.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC₅₀=0.043 μM), aromatase/CYP19A1 (IC₅₀=2.8 μM), PTPase 1B (IC₅₀=1.26 μM), and COX (IC₅₀=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases.

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Purity : 97.25%
CAS No.: 14917-41-0
화학식: C₁₅H₁₂O₆
분자량:288.25

보관:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Eriodictyol chalcone Chemical Structure

CAS No.: 14917-41-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Aromatase

Plasmodium falciparum sporozoites

All Cytochrome P450 Isoforms :

All Parasite Isoforms :

All COX Isoforms :

All Lipoxygenase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	4.4 μM Compound: 1	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
Neutrophil	IC₅₀	5 μM Compound: 1	Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method	[PMID: 33006891]
RBL-1	IC₅₀	0.14 μM Compound: 12	Inhibition of 5-lipoxygenase in rat RBL1 cells Inhibition of 5-lipoxygenase in rat RBL1 cells	10.1007/s00044-013-0745-7
RBL-1	IC₅₀	0.14 μM Compound: 12	Inhibition of cyclooxygenase in rat RBL1 cells Inhibition of cyclooxygenase in rat RBL1 cells	10.1007/s00044-013-0745-7
RBL-1	IC₅₀	0.14 μM Compound: 13	In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined	[PMID: 8254620]

In Vitro

Eriodictyol chalcone (1 mM; 48 h) inhibits growth of the 3D7 Plasmodium falciparum strain by 88% when used at 1 mM for 48 h^[1].
Eriodictyol chalcone (2.5-8.2 μM) inhibits phosphoenolpyruvate carboxylase (PEPC) with IC₅₀ values of 2.5 μM and 8.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Eriodictyol chalcone (10 mg/kg) exerts potent antidepressant activity in mice, as evidenced by a statistically significant reduction in immobility duration in the forced swimming test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 14917-41-0
Appearance Solid
분자량 288.25
화학식 C₁₅H₁₂O₆
Color Yellow to orange
SMILES

O=C(C1=C(O)C=C(O)C=C1O)/C=C/C2=CC=C(O)C(O)=C2
Structure Classification
- Flavonoids
- Chalcones
- Phenols
- Polyphenols
Initial Source
- Plants
- Umbelliferae
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 30 mg/mL (104.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4692 mL

17.3461 mL

34.6921 mL

5 mM

0.6938 mL

3.4692 mL

6.9384 mL

10 mM

0.3469 mL

1.7346 mL

3.4692 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chacon-Morales P A, et al. Chalcone-flavanone equilibrium in the isomeric mixture: 2', 3, 4, 4', 6'-Pentahydroxychalcone and eriodictyol from Stevia lucida[J]. Avances en Quimica, 2020, 15(3): 89-96.

[2]. Iijima Y, et al. Metabolite profiling of chalcones and flavanones in tomato fruit[J]. Journal of the Japanese Society for Horticultural Science, 2008, 77(1): 94-102.

[3]. Furudate H, et al. A Polyphenol Oxidase Catalyzes Aurone Synthesis in Marchantia polymorpha. Plant Cell Physiol. 2023;64(6):637-645. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4692 mL	17.3461 mL	34.6921 mL	86.7303 mL
	5 mM	0.6938 mL	3.4692 mL	6.9384 mL	17.3461 mL
	10 mM	0.3469 mL	1.7346 mL	3.4692 mL	8.6730 mL
	15 mM	0.2313 mL	1.1564 mL	2.3128 mL	5.7820 mL
	20 mM	0.1735 mL	0.8673 mL	1.7346 mL	4.3365 mL
	25 mM	0.1388 mL	0.6938 mL	1.3877 mL	3.4692 mL
	30 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8910 mL
	40 mM	0.0867 mL	0.4337 mL	0.8673 mL	2.1683 mL
	50 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7346 mL
	60 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4455 mL
	80 mM	0.0434 mL	0.2168 mL	0.4337 mL	1.0841 mL
	100 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8673 mL

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Eriodictyol chalcone

All Cytochrome P450 Isoforms

All Parasite Isoforms

All COX Isoforms

All Lipoxygenase Isoforms