Fosmidomycin
Based on 2 publication(s) in Google Scholar
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model.
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- CAS No.: 66508-53-0
- 화학식: C4H10NO5P
- 분자량:183.10
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Fosmidomycin
MoreAll Antibiotic Isoforms
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Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | IC50 |
>62 μM
Compound: 1
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Cytotoxicity against human MRC5 cells
Cytotoxicity against human MRC5 cells
|
[PMID: 21866890] |
Chemical Information
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CAS No. 66508-53-0
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분자량 183.10
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화학식 C4H10NO5P
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SMILES
OP(O)(CCCN(C=O)O)=O
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Structure Classification
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Initial Source
Streptomyces lavendulae
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Plant Sci
Adjusting function of camphor on primary metabolism in Cinnamomum camphora stressed by high temperature. [Abstract]2024 Feb:339:111956. PMID: 38101618 -
ACS Infect Dis
Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum. [Abstract]2024 Dec 13;10(12):4073-4086. PMID: 39631773
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)