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Cat. No.: HY-N21740

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Furohyperforin

Furohyperforin is a natural product isolated from Hypericum perforatum L., possessing neuroprotective and antidepressant activities. Furohyperforin acts as an NLRP3 inflammasome inhibitor and also exhibits inhibitory effects on recombinant CYP3A4. Furohyperforin exerts neuroprotective effects against corticosterone-induced neuronal damage. Furohyperforin inhibits the NLRP3 inflammasome cascade and its downstream IL‑1β and GSDMD signaling pathways, and also reduces serum corticosterone levels in mice, regulating HPA axis function. Furohyperforin is applicable for depression-related research.

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CAS No.: 219793-20-1
화학식: C₃₅H₅₂O₅
분자량:552.78

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Furohyperforin Chemical Structure

CAS No.: 219793-20-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]^[2]

CYP3A4

NLRP3

IL-1β

All Cytochrome P450 Isoforms :

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

In Vitro

OthersInflammasomePyroptosisInnate Immunity

Others

Furohyperforin inhibits recombinant CYP3A4 enzyme activity with an IC₅₀ of 1.3 μM^[1].
Furohyperforin (compound 7) (10 μM) protects SH-SY5Y cells against CORT-induced injury^[2].
Furohyperforin (10-50 μM; 24 h) inhibits LPS-induced BV2 cell injury and shows no cytotoxicity to BV2 cells^[2].
Furohyperforin exhibits weak inhibitory activity on synaptosomal serotonin uptake in rat brain synaptosomes^[4].
Furohyperforin (compound 10) (10 μg/mL; 2 h pretreatment before KCl injury induction) shows no activity against KCl-induced SH-SY5Y cell injury and no activity against CORT-induced PC12 cell injury, indicating that the β-orientation of the substituent is crucial for neuroprotective activity^[5].

Inflammasome

Pyroptosis

Innate Immunity

Furohyperforin (5-20 μM; 30 min) inhibits NLRP3 inflammasome activation in LPS/nigericin-stimulated BV2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

BV2
Concentration:

5, 10, 20 μM
Incubation Time:

30 min
Result:

Significantly inhibited the release of NLRP3, ASC, caspase-1, and pro-caspase-1.
Reduced the expression levels of IL-1β, pro-IL-1β, and GSDMD.

Cell Cytotoxicity Assay^[2]

Cell Line:

BV2
Concentration:

10, 20 μM
10, 20, 50 μM
Incubation Time:

24 h
Result:

Inhibited LPS-induced BV2 cell injury and showed no cytotoxicity to BV2 cells.

Cell Viability Assay^[5]

Cell Line:

SH-SY5Y, PC12
Concentration:

10 μg/mL
Incubation Time:

2 h pre-treatment prior to 24 h KCl or CORT injury induction
Result:

Was inactive in the KCl-induced SH-SY5Y cell injury model.
Was inactive in the CORT-induced PC12 cell injury model.

In Vivo

Furohyperforin (compound 7) (1.25-5 mg/kg) exhibits significant antidepressant activity in mice, comparable to Fluoxetine (HY-B0102) and Neurostan, and reduces serum CORT levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Pyroptosis Solutions

Chemical Information

CAS No. 219793-20-1
분자량 552.78
화학식 C₃₅H₅₂O₅
SMILES

O=C1[C@@]23C(O[C@@H](C3)C(C)(O)C)=C(C([C@@]1([C@@](C)([C@H](C2)C/C=C(C)\C)CC/C=C(C)/C)C(C(C)C)=O)=O)C/C=C(C)\C
Structure Classification
- Others
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lee JY, et al. Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry. 2006 Dec;67(23):2550-60.

[2]. Pan XG, et al. NOD-like receptor protein 3 inhibitors in St. John's wort and their potential antidepressant effects. International journal of biological macromolecules. 2025 May;306(Pt 4):141721.

[3]. Galeotti N, et al. St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. Biochemical pharmacology. 2010 May 01;79(9):1327-36.

[4]. Jensen AG, et al. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life sciences. 2001 Feb 23;68(14):1593-605.

[5]. Zeng YR, et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum. Journal of Asian natural products research. 2021 Jan 2;23(1):73-81.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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Furohyperforin

All Cytochrome P450 Isoforms

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms