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Cat. No.: HY-10681S1

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Gedatolisib-d₆

Name: Gedatolisib-d6
Brand: MedChemExpress
SKU: HY-10681S1
Availability: PreOrder

(Synonyms: PKI-587-d₆; PF-05212384-d₆)

Gedatolisib-d₆ (PKI-587-d₆) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₂H₃₅D₆N₉O₄
분자량:621.76

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Gedatolisib-d₆ Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- 신청
Chemical Information
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Biological Activity

제품 설명

Gedatolisib-d₆ (PKI-587-d₆) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively^[1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2^[2].

All mTOR Isoforms :

All PI3K Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 1197160-78-3
분자량 621.76
화학식 C₃₂H₃₅D₆N₉O₄
SMILES

O=C(NC1=CC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)NC5=CC=C(C=C5)C(N6CCC(CC6)N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O
Synonyms

PKI-587-d₆; PF-05212384-d₆
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.