Cat. No.: HY-107549

KD 5170

Name: KD 5170
Brand: MedChemExpress
SKU: HY-107549
Price: 120.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

KD 5170 is a pan inhibitor of histone deacetylases (HDACs) and exhibits broad spectrum antitumor activity in vitro and in vivo.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 98.13%
CAS No.: 940943-37-3
화학식: C₂₀H₂₅N₃O₅S₂
분자량:451.56

보관:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

KD 5170 Chemical Structure

CAS No.: 940943-37-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

KD 5170 is a pan inhibitor of histone deacetylases (HDACs) and exhibits broad spectrum antitumor activity in vitro and in vivo^[1].

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	EC₅₀	0.59 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human 786-0 cells Cytotoxicity against human 786-0 cells	[PMID: 18954983]
HCT-116	EC₅₀	0.14 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 18954983]
HeLa	EC₅₀	0.045 μM Compound: Table 1, R10C1, KD5170	Inhibition of HDAC in human HeLa cells assessed as histone H3 hyperacetylation Inhibition of HDAC in human HeLa cells assessed as histone H3 hyperacetylation	[PMID: 18954983]
HeLa	EC₅₀	25 nM Compound: 27, KD5170	Inhibition of HDAC in human HeLa cells assessed as histone H3 hyperacetylation after 7 hrs Inhibition of HDAC in human HeLa cells assessed as histone H3 hyperacetylation after 7 hrs	10.1039/C1MD00199J
HeLa	EC₅₀	325 nM Compound: 27, KD5170	Inhibition of HDAC in human HeLa cells assessed as alpha-tubulin acetylation after 7 hrs Inhibition of HDAC in human HeLa cells assessed as alpha-tubulin acetylation after 7 hrs	10.1039/C1MD00199J
HeLa	IC₅₀	45 nM Compound: 27, KD5170	Inhibition of HDAC isolated from human HeLa cell nuclear extracts using Fluor de Lys as substrate after 30 mins by fluorescence assay Inhibition of HDAC isolated from human HeLa cell nuclear extracts using Fluor de Lys as substrate after 30 mins by fluorescence assay	10.1039/C1MD00199J
HL-60	EC₅₀	0.39 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human HL60 cells Cytotoxicity against human HL60 cells	[PMID: 18954983]
HT-29	EC₅₀	1 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 18954983]
MDA-MB-435	EC₅₀	0.18 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human MDA-MB-435 cells Cytotoxicity against human MDA-MB-435 cells	[PMID: 18954983]
NCI-H460	EC₅₀	0.23 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human H460 cells Cytotoxicity against human H460 cells	[PMID: 18954983]
PC-3	EC₅₀	0.74 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 18954983]
SK-OV-3	EC₅₀	0.76 μM Compound: Table 1, R10C1, KD5170	Cytotoxicity against human SKOV3 cells Cytotoxicity against human SKOV3 cells	[PMID: 18954983]

Chemical Information

CAS No. 940943-37-3
Appearance Solid
분자량 451.56
화학식 C₂₀H₂₅N₃O₅S₂
Color White to yellow
SMILES

O=S(NC1=CC=C(C(CSC(C)=O)=O)C=N1)(C2=CC=C(OCCCN(C)C)C=C2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (221.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2145 mL

11.0727 mL

22.1455 mL

5 mM

0.4429 mL

2.2145 mL

4.4291 mL

10 mM

0.2215 mL

1.1073 mL

2.2145 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (5.54 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (5.54 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (5.54 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hassig CA, et al. KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther. 2008 May;7(5):1054-65. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2145 mL	11.0727 mL	22.1455 mL	55.3636 mL
	5 mM	0.4429 mL	2.2145 mL	4.4291 mL	11.0727 mL
	10 mM	0.2215 mL	1.1073 mL	2.2145 mL	5.5364 mL
	15 mM	0.1476 mL	0.7382 mL	1.4764 mL	3.6909 mL
	20 mM	0.1107 mL	0.5536 mL	1.1073 mL	2.7682 mL
	25 mM	0.0886 mL	0.4429 mL	0.8858 mL	2.2145 mL
	30 mM	0.0738 mL	0.3691 mL	0.7382 mL	1.8455 mL
	40 mM	0.0554 mL	0.2768 mL	0.5536 mL	1.3841 mL
	50 mM	0.0443 mL	0.2215 mL	0.4429 mL	1.1073 mL
	60 mM	0.0369 mL	0.1845 mL	0.3691 mL	0.9227 mL
	80 mM	0.0277 mL	0.1384 mL	0.2768 mL	0.6920 mL
	100 mM	0.0221 mL	0.1107 mL	0.2215 mL	0.5536 mL

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KD 5170

All HDAC Isoforms