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Cat. No.: HY-170890

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Largazole thiol

Largazole thiol, the active form of Largazole (HY-13906), is a potent, selective and brain-penetrant class I HDAC inhibitor. Largazole thiol. Largazole thiol exerts antitumor and neuroprotective effects. Largazole thiol can be used for research of Glioblastoma.

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CAS No.: 1132667-11-8
화학식: C₂₁H₂₈N₄O₄S₃
분자량:496.67

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Largazole thiol Chemical Structure

CAS No.: 1132667-11-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	5.9 nM Compound: 2	Antiproliferative activity against human HCT116 cells after 48 hrs in absence of DTT by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs in absence of DTT by MTT assay	[PMID: 25147612]

Chemical Information

CAS No. 1132667-11-8
분자량 496.67
화학식 C₂₁H₂₈N₄O₄S₃
SMILES

C[C@@]12N=C(SC2)C3=CSC(CNC(C[C@H](OC([C@H](NC1=O)C(C)C)=O)/C=C/CCS)=O)=N3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Al-Awadhi FH, et al. Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases. ACS Chem Neurosci. 2020 Jul 1;11(13):1937-1943. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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Largazole thiol

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Largazole thiol Related Classifications

HY-170890 Related Classifications