Moroxydine
Based on 1 publication(s) in Google Scholar
Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].
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- CAS No.: 3731-59-7
- 화학식: C6H13N5O
- 분자량:171.20
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Moroxydine
MoreAll Caspase Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
Caspase 3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
>2.0 × 105M
Compound: COVC-1214483276
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
In Vitro
Moroxydine hydrochloride (HY-B0420A) used in papers
Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against grass carp reovirus (GCRV) in Ctenopharyngodon idella kidney (CIK) cells (TC50 = 1246.0 μg/mL, SC = 218.5 μg/mL) and grass carp ovary (GCO) cells (TC50 = 117.2 μg/mL, SC = 140.9 μg/mL)[1][2].
Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against giant salamander iridovirus (GSIV) in epithelioma papulosum cyprinid (EPC) cells, with a TC50 of 1486.3 μg/mL and a safe concentration (SC) of 209.7 μg/mL[2].
Moroxydine (40 μg/mL, 48-96 h) blocks the virus-induced CPE and cell death within 96 h and maintained the normal structure and nucleocapsids[1].
Moroxydine (40 μg/mL, 48-96 h) significantly decreases the apoptosis in CIK cells (GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].
Moroxydine (12-48 h) significantly inhibits the caspase 3 activity, Bax expression and down-regulates Bcl-2 at 48 h in CIK cells[1].
Moroxydine (20 μg/mL, 12-72 h) shows time-dependent suppression of viral gene expression in CIK cells(GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].
Moroxydine (20 μg/mL, 72 h) arrests cell cycle in the period of G1/S and G2/M of CIK cells[3].
Moroxydine (3-7 days) inhibits the GCRV-induced upregulation of immune genes (IL-1β, IFN-I, TNF-α) in the kidney, liver, muscle and gill[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GCRV infected CIK cells
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Concentration:1, 2.5, 6.3, 15.9, 39.8, 100 μg/mL
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Incubation Time:24, 48, 72, 96 h
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Result:Presented a better protective-efficiency than Ribavirin(HY-B0434).
Showed no significant difference when expose GCRV-infected CIK cells in 39.8 μg/mL compared with virus-free group at 96 h.
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Cell Line:GCRV infected CIK cells
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Concentration:40 μg/mL
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Incubation Time:48 h
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Result:Exhibited a positive inhibition in the GCRV infected cells compared with negative control.
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Cell Line:GCRV infected CIK cells
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Concentration:20 μg/mL
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Incubation Time:72 h
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Result:Arrested cell cycle in the period of G1/S and G2/M of CIK cells
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Cell Line:GCRV infected CIK cells
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Concentration:20 μg/mL
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Incubation Time:12, 24, 48, 72 h
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Result:Suppressed viral genes (vp1, vp2, vp3 and vp4) at 12 h following a slow decrease from 12 h to 72 h post medication.
Inhibited the IL-1β expression.
Chemical Information
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CAS No. 3731-59-7
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Appearance Solid
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분자량 171.20
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화학식 C6H13N5O
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SMILES
N=C(NC(N1CCOCC1)=N)N
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Synonyms
ABOB
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
2024 Sep 19;17(9):1234. PMID: 39338396
순도&문서
References
[1]. Yu XB, et al. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. [Content Brief]
[2]. Yu XB, et al. In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Organ. 2016 Oct 27;121(3):189-199. [Content Brief]
[3]. Yu XB, et al. Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation. Res Vet Sci. 2018 Apr;117:37-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Moroxydine Related Classifications
HY-W016937 Related Classifications
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