Psa-AR
Psa-AR is a PROTAC degrader targeting PSMA, with a Kd of 7.2 nM. Psa-AR exhibits strong degradation capabilities for AR, AR-V7, and HSP90, and induces cell apoptosis. Psa-AR demonstrates potent tumor suppressive activity in the 22Rv1 xenograft tumor model. Psa-AR can be used in the research of castration-resistant prostate cancer.
(Pink: PSMA ligand (HY-179051); Blue: Cereblon ligand (HY-131717); Black: linker).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C110H120F4N22O29S2
- 분자량:2354.38
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
HSP90 |
Cereblon |
Chemical Information
-
분자량 2354.38
-
화학식 C110H120F4N22O29S2
-
SMILES
OC(C(NC(NC(C(O)=O)CCC(O)=O)=O)CCCCNC(C(CC1=CC=C2C(C=CC=C2)=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(CNC3=CC=CC(C(N4C(C(N5)=O)CCC5=O)=O)=C3C4=O)=O)CCCCNC(C(C=CC(N6C(N(C7=CC=C(C(C(F)(F)F)=C7)C#N)C(C6(C)C)=O)=S)=C8)=C8F)=O)=O)CS)=O)CCC(N)=O)=O)CC9=CC=C(C=C9)O)=O)CC(N)=O)=O)CCC(N)=O)=O)CC%10=CC=C(C=C%10)O)=O)CC%11=CC=C(C=C%11)O)=O)=O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Psa-AR Related Classifications
HY-179056 Related Classifications
Powered by Bioz