Cat. No.: HY-N6626

Pyraclostrobin

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.91%
CAS No.: 175013-18-0
화학식: C₁₉H₁₈ClN₃O₄
분자량:387.82

보관:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pyraclostrobin Chemical Structure

CAS No.: 175013-18-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Bax

Bcl-2

All Bcl-2 Family Isoforms :

All mTOR Isoforms :

All AMPK Isoforms :

In Vitro

Pyraclostrobin (10-80 μmol/L, 24 h) exhibits toxic effects in HepG2 cells^[1].
Pyraclostrobin (10-80 μmol/L, 6 h) induced DNA damage and mitochondrial dysfunction in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 cells
Concentration:

10 μmol/L, 20 μmol/L, 40 μmol/L, 80 μmol/L
Incubation Time:

24 h
Result:

Inhibited cell survival in concentration-dependent manner with IC₅₀ value of 30.22 μmol/L.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

10 μmol/L, 20 μmol/L, 40 μmol/L, 80 μmol/L
Incubation Time:

6 h
Result:

Increased the content of cytochrome c (Cyt c) in the cytoplasm in a concentration-dependent way.
Increased pro-apoptotic protein Bax expression and down-regulated anti-apoptosis protein Bcl-2 expression.

In Vivo

Pyraclostrobin (0.01-0.08 μmol/L, Zebrafish larvae were subjected to pyraclostrobin exposure persisting until 72 h post fertilization) results in hepatomegaly in zebrafish larvae^[1].
Pyraclostrobin (0.001-0.02 mg/L, Fish were assigned to a vessel containing 20 L of water dissolved Pyraclostrobin for 7-28 days) has the toxic effects on DNA damage and antioxidant enzymatic activities in the zebrafish liver^[2].
Pyraclostrobin (33-48 μg/L, Zebrafish larvae at 4 days post fertilization (dpf) were transferred into 24-well plates and subjected to pyraclostrobin until 8 dpf) has toxic effects on zebrafish larvae^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Zebrafish ^[2]
Dosage:

0.001 mg/L, 0.01 mg/L, 0.02 mg/L
Administration:

Fish were assigned to a vessel containing 20 L of water dissolved Pyraclostrobin
Result:

Showed higher ROS levels in zebrafish livers.
Decreased SOD levels and increased MDA levels.
Increased the olive tail moments as the dose increased on days 7, 14, 21, and 28.

Animal Model:

Zebrafish larvae ^[3]
Dosage:

33 mg/L, 36 mg/L, 40 mg/L, 44 mg/L, 48 mg/L
Administration:

Zebrafish larvae at 4 days post fertilization (dpf) were transferred into 24-well plates and subjected to pyraclostrobin until 8 dpf
Result:

Damaged histological and subcellular structure of larval heart and brain.
Changed the expression level of cardiac muscle contraction pathway- and neural-related genes and proteins.
Impaired larval cardiac function and locomotor behavior.

Chemical Information

CAS No. 175013-18-0
Appearance Solid
분자량 387.82
화학식 C₁₉H₁₈ClN₃O₄
Color Off-white to light yellow
SMILES

COC(N(C1=C(C=CC=C1)COC2=NN(C3=CC=C(Cl)C=C3)C=C2)OC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Food Res Int

Analysis of pesticide residues in açaí-based food products: an approach using polymeric ionic liquid-based solid-phase microextraction coupled to gas chromatography-mass spectrometry. [Abstract]

2025 Dec;222(Pt 2):117720. PMID: 41271335
Pestic Biochem Physiol

The function of the alternative oxidase gene in the tolerance of Fusarium graminearum to azoxystrobin. [Abstract]

2026 Feb:217:106853. PMID: 41461432

용액&용해도

In Vitro:

DMSO : 100 mg/mL (257.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5785 mL

12.8926 mL

25.7852 mL

5 mM

0.5157 mL

2.5785 mL

5.1570 mL

10 mM

0.2579 mL

1.2893 mL

2.5785 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (5.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (5.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu M, et al. Characterization of hepatotoxic effects induced by pyraclostrobin in human HepG2 cells and zebrafish larvae [J]. Chemosphere, 2023, 340: 139732. [Content Brief]

[2]. Zhang C, et al. Acute and subchronic toxicity of pyraclostrobin in zebrafish (Danio rerio) [J]. Chemosphere, 2017, 188: 510-516. [Content Brief]

[3]. Li H, et al. Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae [J]. Environmental Pollution, 2019, 251: 203-211. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5785 mL	12.8926 mL	25.7852 mL	64.4629 mL
	5 mM	0.5157 mL	2.5785 mL	5.1570 mL	12.8926 mL
	10 mM	0.2579 mL	1.2893 mL	2.5785 mL	6.4463 mL
	15 mM	0.1719 mL	0.8595 mL	1.7190 mL	4.2975 mL
	20 mM	0.1289 mL	0.6446 mL	1.2893 mL	3.2231 mL
	25 mM	0.1031 mL	0.5157 mL	1.0314 mL	2.5785 mL
	30 mM	0.0860 mL	0.4298 mL	0.8595 mL	2.1488 mL
	40 mM	0.0645 mL	0.3223 mL	0.6446 mL	1.6116 mL
	50 mM	0.0516 mL	0.2579 mL	0.5157 mL	1.2893 mL
	60 mM	0.0430 mL	0.2149 mL	0.4298 mL	1.0744 mL
	80 mM	0.0322 mL	0.1612 mL	0.3223 mL	0.8058 mL
	100 mM	0.0258 mL	0.1289 mL	0.2579 mL	0.6446 mL

Keywords

Pyraclostrobin

2 Cited Publications

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Pyraclostrobin

Anti-Infection Compound Library

Apoptosis Compound Library

Epigenetics Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Antifungal Compound Library

Antibacterial Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Mitochondria-Targeted Compound Library

Lipid Metabolism Compound Library

Glucose Metabolism Compound Library

Human Metabolite Library

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Pain-Related Compound Library

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Cell Death Library

Multi-Target Compound Library

Radioprotector Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Environmental Pollutant Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Pyraclostrobin

All Bcl-2 Family Isoforms

All mTOR Isoforms

All AMPK Isoforms

Biological Activity

Chemical Information

Publications (2)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Pyraclostrobin Related Classifications

HY-N6626 Related Classifications