Simotaxel
Simotaxel (MST 997) is an orally active derivative of the taxane class. Simotaxel binds to β-tubulin and promotes tubulin polymerization (EC₅₀ = 0.9 μM), inhibits tubulin depolymerization, and causes cell cycle arrest at the G₂-M phase. Simotaxel disrupts the formation of the mitotic spindle and triggers the caspase-dependent apoptotic pathway (apoptosis). Simotaxel has inhibitory effects on Paclitaxel (HY-B0015) sensitive cell lines and overcomes drug resistance. Simotaxel can be used to study Paclitaxel / Docetaxel (HY-B0011) resistant solid tumors.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 791635-59-1
- 화학식: C46H57NO15S
- 분자량:896.01
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
All Caspase Isoforms
More
Biological Activity
제품 설명
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 791635-59-1
-
분자량 896.01
-
화학식 C46H57NO15S
-
SMILES
O[C@H]1C[C@]2([H])[C@](CO2)(OC(C)=O)[C@]3([H])[C@@]1(C([C@H](OC(C4CCCC4)=O)C5=C(C)[C@@H](OC([C@H](O)[C@@H](NC(OC(C)C)=O)C6=CC=CS6)=O)C[C@]([C@H]3OC(C7=CC=CC=C7)=O)(O)C5(C)C)=O)C
-
Synonyms
MST 997
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Simotaxel Related Classifications
HY-16457 Related Classifications
Powered by Bioz