Polyketides

Averythrin is an antibacterial agent that can be used in studies related to Staphylococcus aureus infections.

Dihydroflavokawain C is a chalcone. Dihydroflavokawain C can be isolated from the leaves of P. gaudichaudianum. Dihydroflavokawain C exhibits no molluscicidal activity against Biomphalaria glabrata.

4'-O-Methylcatechin acts as a lipase and acetylcholinesterase inhibitor, with an IC₅₀ of 149.93 μM against lipase and an IC₅₀ of 230.89 μM against electric eel-derived acetylcholinesterase. 4'-O-Methylcatechin possesses free radical scavenging activity and can be used in studies on antioxidation, antilipase activity and dementia.

4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone is a 3-methoxyflavonoid compound. 4',5-Dihydroxy-3,3',7,8-tetramethoxyflavone inhibits α-Amylase.

Glyceollidin I is an isoflavonoid derivative present in soybean (Glycine max) tissues. Glyceollidin I is produced in soybean tissues in response to biotic or abiotic factors, and serves as a biosynthetic precursor of Glyceollin I (HY-N11785).

Kaempferol 5-methyl ether (5-O-Methylkaempferol) is a flavonoid compound. Kaempferol 5-methyl ether can be isolated from the geopropolis of Melipona subnitida.

Glepidotin A is a flavanol. Glepidotin A can be isolated from the leaves and stems of Glycyrrhiza lepidota. Glepidotin A exhibits no anti-HIV-1 activity.

(+)-Mollisacacidin is a flavan compound found in the root bark of Albizia glaberrima. (+)-Mollisacacidin exhibits no significant antiproliferative effect on cancer cells.

Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria.

Brickellin is an antioxidant agent that can be isolated from Varronia curassavica Jacq.. Brickellin inhibits advanced glycation end products (AGEs) formation, protein crosslinking, and oxidative damage to proteins. Brickellin can be used for the research of diabetes.

Herbacitrin is a HIV-1 reverse transcriptase and integrase inhibitor with IC₅₀ values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection.

5-Deoxykievitone, an isoflavanone found in Phaseolus species, is a GABA receptor modulator. 5-Deoxykievitone potentiates GABA-induced chloride current through α₁β₂γ_2s GABA_A receptors. 5-Deoxykievitone can be used for the research of epilepsy and anxiety.

Glyceocarpin is a phytoalexin and antibacterial agent naturally occurring in Glycine max, with weak antifungal activity. Glyceocarpin serves as the biosynthetic precursor of Glyceollins II (HY-N18032) and Glyceollins III. Glyceocarpin can be biosynthesized by the prenyltransferase and subsequent modification by cytochrome P450 enzymes. Glyceocarpin can be used for the study of soybean root and stem rot caused by Phytophthora sojae.

Hibiscetin is an orally active anti-inflammatory, antioxidant, antihyperglycemic, hypolipidemic, hepatoprotective and neuroprotective agent. Hibiscetin reduces the levels of TNF-α, IL-1β and IL-6. Hibiscetin inhibits lipid peroxidation, reduces MDA levels, and induces the activities of antioxidant enzymes CAT, GSH and SOD. Hibiscetin lowers blood glucose, reverses reduced insulin levels, regulates adipokine levels, and reduces elevated AST and ALT levels. Hibiscetin alleviates Rotenone (HY-B1756)-induced akinesia and catalepsy, normalizes neurotransmitter levels, and modulates the activities of activated caspase 3 and BDNF. Hibiscetin can be used in the research of type 2 diabetes, Parkinson's disease and Huntington's disease.

Quercetin 3-O-(2G-β-D-xylopyranosylrutinoside) is an oviposition inhibitory factor. Quercetin 3-O-(2G-β-D-xylopyranosylrutinoside) can be isolated from the leaves of Orixa japonica. When presented together with the oviposition stimulant from Citrus unshiu (Satsuma mandarin), Quercetin 3-O-(2G-β-D-xylopyranosylrutinoside) inhibits oviposition by gravid female Papilio xuthus (Asian swallowtail).

Uralene is a flavonoid compound found in the leaves of Glycyrrhiza uralensis Fisch.

Neouralenol is a free radical scavenger. Neouralenol can be isolated from licorice roots. Neouralenol scavenges hydroxyl radicals and hydroperoxyl radicals.