1. PROTAC
    Epigenetics
    Antibody-drug Conjugate/ADC Related
  2. PROTAC
    Epigenetic Reader Domain
    ADC Cytotoxin
  3. PROTAC BRD4 Degrader-10

PROTAC BRD4 Degrader-10 

Cat. No.: HY-138633
Handling Instructions

PROTAC BRD4 Degrader-10 (compound 8b) is a potent BRD4 degrader. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively.

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-10 Chemical Structure

PROTAC BRD4 Degrader-10 Chemical Structure

CAS No. : 2417370-49-9

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Description

PROTAC BRD4 Degrader-10 (compound 8b) is a potent BRD4 degrader. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively[1].

Molecular Weight

1312.50

Formula

C₅₉H₇₁F₂N₉O₁₅S₄

CAS No.
SMILES

CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]](CN3C([[email protected]@H](NC(COCCOCCOCCNC(C4=CC(N(C5=NC=C(F)C=C5F)CC6=CNC7=C6C8=CN(C)C7=O)=C8C=C4CS(=O)(C)=O)=O)=O)C(C)(C)C)=O)OC(OC(C)C(C)SS(C)(=O)=O)=O)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PROTAC BRD4 Degrader-10PROTACEpigenetic Reader DomainADC CytotoxinProteolysis-targeting chimeraSTEAP1antibodiesPC3prostatecancerInhibitorinhibitorinhibit

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PROTAC BRD4 Degrader-10
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