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Cat. No.: HY-177041

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PROTAC BRD4 Degrader-35

PROTAC BRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4, which is formed by coupling a BRD4 inhibitor active moiety with an HSP90-binding fragment via a linker. PROTAC BRD4 Degrader-35 can be used in cancer-related research.
(Pink: BRD4 ligand (HY-78695); Blue: HSP90 ligand (HY-177042); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2503035-53-6
Formula: C₄₇H₅₃ClN₁₀O₄S
Molecular Weight:889.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

PROTAC BRD4 Degrader-35 Chemical Structure

CAS No.: 2503035-53-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC BRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4, which is formed by coupling a BRD4 inhibitor active moiety with an HSP90-binding fragment via a linker. PROTAC BRD4 Degrader-35 can be used in cancer-related research^[1]. (Pink: BRD4 ligand (HY-78695); Blue: HSP90 ligand (HY-177042); Black: linker).

IC₅₀ & Target

^[1]

BRD4

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2503035-53-6
Molecular Weight 889.51
Formula C₄₇H₅₃ClN₁₀O₄S
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCC(CC4)CN5CCN(CC5)CC6=CC=C(N7C(C8=CC(C(C)C)=C(C=C8O)O)=NNC7=O)C=C6)=O)C9=NN=C(C)N29
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mark T. Bilodeau, et al., HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF REFERENCED TO RELATED APPLICATIONS. WO2022235889A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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