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製品番号: HY-177041

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PROTAC BRD4 Degrader-35

PROTAC BRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4, which is formed by coupling a BRD4 inhibitor active moiety with an HSP90-binding fragment via a linker. PROTAC BRD4 Degrader-35 can be used in cancer-related research.
(Pink: BRD4 ligand (HY-78695); Blue: HSP90 ligand (HY-177042); Black: linker).

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CAS 番号: 2503035-53-6
分子式: C₄₇H₅₃ClN₁₀O₄S
分子量:889.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

PROTAC BRD4 Degrader-35 構造式

CAS 番号: 2503035-53-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PROTAC BRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4, which is formed by coupling a BRD4 inhibitor active moiety with an HSP90-binding fragment via a linker. PROTAC BRD4 Degrader-35 can be used in cancer-related research^[1]. (Pink: BRD4 ligand (HY-78695); Blue: HSP90 ligand (HY-177042); Black: linker).

IC₅₀ & Target

^[1]

BRD4

PROTACs アイソフォーム固有の製品をすべて表示 :

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示 :

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2503035-53-6
分子量 889.51
分子式 C₄₇H₅₃ClN₁₀O₄S
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCC(CC4)CN5CCN(CC5)CC6=CC=C(N7C(C8=CC(C(C)C)=C(C=C8O)O)=NNC7=O)C=C6)=O)C9=NN=C(C)N29
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Mark T. Bilodeau, et al., HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF REFERENCED TO RELATED APPLICATIONS. WO2022235889A1.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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