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Cat. No.: HY-177041

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PROTAC BRD4 Degrader-35

PROTAC BRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4, which is formed by coupling a BRD4 inhibitor active moiety with an HSP90-binding fragment via a linker. PROTAC BRD4 Degrader-35 can be used in cancer-related research.
(Pink: BRD4 ligand (HY-78695); Blue: HSP90 ligand (HY-177042); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2503035-53-6
Formule: C₄₇H₅₃ClN₁₀O₄S
Masse moléculaire:889.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

PROTAC BRD4 Degrader-35 Chemical Structure

CAS No.: 2503035-53-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PROTAC BRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4, which is formed by coupling a BRD4 inhibitor active moiety with an HSP90-binding fragment via a linker. PROTAC BRD4 Degrader-35 can be used in cancer-related research^[1]. (Pink: BRD4 ligand (HY-78695); Blue: HSP90 ligand (HY-177042); Black: linker).

IC₅₀ & Target

^[1]

BRD4

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2503035-53-6
Masse moléculaire 889.51
Formule C₄₇H₅₃ClN₁₀O₄S
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCC(CC4)CN5CCN(CC5)CC6=CC=C(N7C(C8=CC(C(C)C)=C(C=C8O)O)=NNC7=O)C=C6)=O)C9=NN=C(C)N29
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mark T. Bilodeau, et al., HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF REFERENCED TO RELATED APPLICATIONS. WO2022235889A1.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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