PROTAC BRD4 Degrader-55
PROTAC BRD4 Degrader-55 is a BRD4 PROTAC degrader with a DC50 of 35 nM. PROTAC BRD4 PROTAC BRD4 Degrader-55 can be used for research on cervical cancer.
(Pink: BRD4 ligand (HY-13030); Blue: Cereblon ligand (HY-138793); Black: linker).
For research use only. We do not sell to patients.
- Formula: C40H36N6O5S
- Molecular Weight:712.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
BRD4 35 nM (DC50) |
Cereblon |
In Vitro
PROTAC BRD4 Degrader-55 (30 nM; 6 h) downregulates BRD4 in HeLa whole-cell proteomics, with higher selectivity for BRD4 than for BRD2/BRD3[1].
PROTAC BRD4 Degrader-55 reduces BRD4 foci in HeLa cells, with a DC50 of 35 nM after 24 h[1].
PROTAC BRD4 Degrader-55 (150 nM) induced BRD4 degradation in HeLa cells is blocked by proteasome inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:300 nM
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Incubation Time:24 h
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Result:Induced the degradation of more than 90% of BRD4.
Chemical Information
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Molecular Weight 712.82
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Formula C40H36N6O5S
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SMILES
CC1=C(C)C(C(C2=CC=C(C#CC#CC3=CC=CC4=C3CN(C5CCC(NC5=O)=O)C4=O)C=C2)=N[C@H]6CC(OC(C)(C)C)=O)=C(N7C6=NN=C7C)S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC BRD4 Degrader-55 Related Classifications
HY-188419 Related Classifications
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