Psa-AR
Psa-AR is a PROTAC degrader targeting PSMA, with a Kd of 7.2 nM. Psa-AR exhibits strong degradation capabilities for AR, AR-V7, and HSP90, and induces cell apoptosis. Psa-AR demonstrates potent tumor suppressive activity in the 22Rv1 xenograft tumor model. Psa-AR can be used in the research of castration-resistant prostate cancer.
(Pink: PSMA ligand (HY-179051); Blue: Cereblon ligand (HY-131717); Black: linker).
For research use only. We do not sell to patients.
- Formula: C110H120F4N22O29S2
- Molecular Weight:2354.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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HSP90 |
Cereblon |
Chemical Information
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Molecular Weight 2354.38
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Formula C110H120F4N22O29S2
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SMILES
OC(C(NC(NC(C(O)=O)CCC(O)=O)=O)CCCCNC(C(CC1=CC=C2C(C=CC=C2)=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC(CNC3=CC=CC(C(N4C(C(N5)=O)CCC5=O)=O)=C3C4=O)=O)CCCCNC(C(C=CC(N6C(N(C7=CC=C(C(C(F)(F)F)=C7)C#N)C(C6(C)C)=O)=S)=C8)=C8F)=O)=O)CS)=O)CCC(N)=O)=O)CC9=CC=C(C=C9)O)=O)CC(N)=O)=O)CCC(N)=O)=O)CC%10=CC=C(C=C%10)O)=O)CC%11=CC=C(C=C%11)O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Psa-AR Related Classifications
HY-179056 Related Classifications
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