Cefonicid
Cefonicid is a long-acting cephalosporin antibiotic. Cefonicid is also a non-competitive type I β-lactamase with a Ki value of 0.8 μM. Cefonicid exhibits broad-spectrum antibacterial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid binds PBP1a, PBP1b, and PBP3, inhibiting peptidoglycan synthesis and leading to filamentation and lysis. Cefonicid can be used for research on infections.
For research use only. We do not sell to patients.
- CAS No.: 61270-58-4
- Formula: C18H18N6O8S3
- Molecular Weight:542.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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PBP1a |
PBP1b |
PBP3 |
In Vitro
Cefonicid (0-24 h) exhibits concentration-dependent bactericidal activity against Klebsiella pneumoniae strain 2603 in vitro, with an MIC of 0.25 mg/L[3].
Cefonicid binds to PBPs of E. coli K-12 KN-126, with the highest affinity for PBP 1a, followed by PBP 3, and does not significantly bind PBP 5 or 6[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Cefonicid (40 mg/kg; single dose) exhibits excellent protective efficacy against S. aureus, E. coli, P. mirabilis, and K. pneumoniae infections in mice[4].
Cefonicid has excellent prophylactic protective efficacy against surgical wound infections in mice, with an ED50 value of ≤2.1 mg/kg against Gram-negative bacilli and an ED50 value of 3.7 to 8.7 mg/kg against S. aureus[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hartley (female, 220-250 g)[3]
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Dosage:15 mg/kg
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Administration:i.p.; 2 doses (immediately and 24 hours post-challenge)
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Result:Showed similar lung bacterial counts to infected untreated controls at 0 and 1 hour post-challenge.
Reduced lung bacterial counts significantly compared to infected untreated controls starting at 6 hours post-challenge, with significant reductions also seen at 24 and 48 hours post-challenge.
Chemical Information
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CAS No. 61270-58-4
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Molecular Weight 542.57
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Formula C18H18N6O8S3
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SMILES
O=C(O)C(N12)=C(CSC3=NN=NN3CS(=O)(O)=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107. [Content Brief]
[4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259. [Content Brief]
[5]. Rake JB, et al. Affinity of cefonicid, a long-acting cephalosporin, for the penicillin-binding proteins of Escherichia coli K-12. The Journal of antibiotics. 1984 May;37(5):572-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cefonicid Related Classifications
HY-B1300A Related Classifications
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Keywords
- Cefonicid
- 61270-58-4
- Bacterial
- Antibiotic
- Beta-lactamase
- Interleukin Related
- Penicillin-binding protein (PBP)
- Bacteroides fragilis
- CD4+ T-helper cells
- Enterobacter cloacae
- Klebsiella pneumoniae
- beta-lactamase
- interleukin-2
- penicillin-binding protein 1a
- penicillin-binding protein 1b
- penicillin-binding protein 3
- peptidoglycan synthesis
- Inhibitor
- inhibitor
- inhibit