157 Results for "

Nrf2/HO-1

" in MedChemExpress (MCE) Product Catalog:
Products (157)

157 Results for "Nrf2/HO-1" in MCE Product Catalog:

2
Dihydrolipoic Acid
Dihydrolipoic Acid
0 Images
2 Cited Publications
Cat. No.: HY-116807
CAS No.: 462-20-4
Purity:  99.95%
Synonyms: DHLA
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

Reactive Oxygen Species (ROS)

Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical [1]. Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression [2].
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Coenzyme Q0
Coenzyme Q0
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2 Cited Publications
Cat. No.: HY-W016412
CAS No.: 605-94-7
Synonyms: CoQ0
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling [1] [2] .
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4-Hydroxyphenyl acetate
4-Hydroxyphenyl acetate
0 Images
2 Cited Publications
Cat. No.: HY-30267
CAS No.: 3233-32-7
Synonyms: 4-HPA; 4-Acetoxyphenol
Category:  

Monophenols Other Diseases Phenols Endogenous metabolite Disease Research Fields

Target:  

Quinone Reductase Endogenous Metabolite

4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor [1].
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5,7-Dihydroxychromone
5,7-Dihydroxychromone
0 Images
2 Cited Publications
Cat. No.: HY-N1970
CAS No.: 31721-94-5
Category:  

Flavonoids Phenols Polyphenols Plants Other Families Extract Isoflavones

Target:  

Keap1-Nrf2 Caspase PARP Fungal

5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection [1] [2] .
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Methylnissolin-3-O-glucoside
Methylnissolin-3-O-glucoside
0 Images
2 Cited Publications
Cat. No.: HY-N2473
CAS No.: 94367-42-7
Category:  

Flavonoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Leguminosae Extract Plants Disease Research Fields Inflammation/Immunology Other Flavonoids

Target:  

Drug Derivative Akt Keap1-Nrf2 Heme Oxygenase (HO) Quinone Reductase MEK ERK Free Radical Scavengers

Methylnissolin-3-O-glucoside is a flavonoid glycoside derivative of Methylnissolin (HY-N2484). Methylnissolin-3-O-glucoside is isolated from plants of the genus Astragalus (Leguminosae). Methylnissolin-3-O-glucoside effectively induces the expression of AKT/Nrf2 and its downstream target genes HO-1 and NQO1. Methylnissolin-3-O-glucoside inhibits TNF-α-induced phosphorylation of MEK and ERK . Methylnissolin-3-O-glucoside exhibits free radical scavenging activity. Methylnissolin-3-O-glucoside inhibits cell proliferation and cell migration. Methylnissolin-3-O-glucoside is used in research on esophageal squamous cell carcinoma [1] [2] .
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DI-1859
DI-1859
0 Images
2 Cited Publications
Cat. No.: HY-145733
CAS No.: 2247061-09-0
Purity:  99.62%
Target:  

E1/E2/E3 Enzyme Keap1-Nrf2 Reactive Oxygen Species (ROS) Insulin Receptor Akt

Research Areas:  

Metabolic Disease Cancer

DI-1859 is a DCN1 and cullin 3 inhibitor with a Ki of <1 nM against human DCN1. DI-1859 forms a covalent bond with Cys115 of DCN1, cleaves its dimethylamino group, disrupts the DCN1-UBC12 interaction, and selectively inhibits the neddylation modification of cullin 3 relative to other cullins. DI-1859 inactivates CRL3, promotes the accumulation of NRF2 and SLC7A11, upregulates the expression of HO-1 and NQO1, reduces reactive oxygen species (ROS) levels, enhances insulin signaling, promotes insulin secretion, activates RhoA, regulates the phosphorylation of AKT, without completely blocking the neddylation modification of cullin 3 or restoring the expression of IRS-1. DI-1859 can be used in the research of Acetaminophen (HY-66005)-induced hepatotoxicity, hyperglycemia, metabolic dysfunction-associated steatotic liver disease, insulin resistance, breast cancer and lung cancer [1] [2] .
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Senkyunolide I
Senkyunolide I
0 Images
2 Cited Publications
Cat. No.: HY-N0745
CAS No.: 94596-28-8
Category:  

Natural Products Umbelliferae Extract Dicerothamnus rhinocerotis Plants Disease Research Fields Inflammation/Immunology

Target:  

Caspase ERK Keap1-Nrf2 Heme Oxygenase (HO) Apoptosis

Senkyunolide I is an orally active, blood-brain barrier-permeable metabolite of Z-ligustilide (HY-N0401A) . Senkyunolide I is isolated from Ligusticum chuanxiong. Senkyunolide I upregulates p-Erk1/2 and Nrf2/HO-1, and inhibits Caspase 3. Senkyunolide I alleviates Apoptosis. Senkyunolide I increases the pain threshold in mice and reduces acetic acid-induced writhing responses in mice. Senkyunolide I improves neurological deficits, reduces infarct volume and alleviates cerebral edema in rats with focal cerebral ischemia-reperfusion injury. Senkyunolide I protects renal function and structural integrity in a mouse model of renal ischemia-reperfusion injury. Senkyunolide I is applicable to research related to focal cerebral ischemia-reperfusion injury, migraine, and renal ischemia-reperfusion injury [1] [2] .
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Curdione
Curdione
0 Images
2 Cited Publications
Cat. No.: HY-N0353
CAS No.: 13657-68-6
Synonyms: (+)-Curdione
Category:  

Zingiberaceae Extract Terpenoids Sesquiterpenes Other Diseases Plants Curcuma phaeocaulis Valeton Disease Research Fields

Target:  

Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)

Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC50 = 1.1 μM) and cyclooxygenase 2 expression [1] [2] .
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Thiamine hydrochloride
Thiamine hydrochloride
0 Images
2 Cited Publications
Cat. No.: HY-N0680
CAS No.: 67-03-8
Synonyms: Thiamine chloride hydrochloride; Vitamin B1 hydrochloride
Category:  

Human Gut Microbiota Metabolites Natural Products Endogenous metabolite

Target:  

Endogenous Metabolite Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB

Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis [1] [2] .
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Alirocumab
Alirocumab
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1 Cited Publications
Cat. No.: HY-P9928
CAS No.: 1245916-14-6
Synonyms: REGN 727; SAR 236553

Target:  

PCSK9 NOD-like Receptor (NLR) Keap1-Nrf2 HMG Family NF-κB CX3CR1

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Alirocumab is an anti-PCSK9 human monoclonal antibody. Alirocumab inhibits PCSK9. Alirocumab reduces NLRP3 inflammasome, regulates Nrf2/HO-1, HMGB1/NF-κB and Fractalkine/CX3CR1. Alirocumab increases the ability of the liver to bind LDL-cholesterol (LDL-C) and reduces levels of LDL-C in blood. Alirocumab improves atherosclerosis and inflammation [1] [2] .
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Pelargonidin chloride
Pelargonidin chloride
0 Images
1 Cited Publications
Cat. No.: HY-W011370
CAS No.: 134-04-3
Category:  

Anthocyans Flavonoids Other Diseases Phenols Polyphenols Leguminosae Extract Plants Phaseolus vulgaris Linn. Disease Research Fields

Target:  

Quinone Reductase Reactive Oxygen Species (ROS)

Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment [1] [2] .
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Quinocetone
Quinocetone
0 Images
1 Cited Publications
Cat. No.: HY-123581
CAS No.: 81810-66-4
Purity:  98.00%
Target:  

Antibiotic Bacterial ATF6 DAPK Autophagy NF-κB NO Synthase Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 Heme Oxygenase (HO)

Research Areas:  

Infection Inflammation/Immunology

Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage [1] [2] .
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Tricetin
Tricetin
0 Images
1 Cited Publications
Cat. No.: HY-131592
CAS No.: 520-31-0
Purity:  97.73%
Category:  

Flavonols Flavonoids Neurological Disease Thuja occidentalisLinn. Plants Disease Research Fields Inflammation/Immunology Cupressaceae Extract

Target:  

Apoptosis Keap1-Nrf2

Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway [1].
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Picein
Picein
0 Images
1 Cited Publications
Cat. No.: HY-N8698
CAS No.: 530-14-3
Category:  

Nyssaceae Extract Plants Saccharides

Target:  

SOD Ferroptosis Keap1-Nrf2 Heme Oxygenase (HO) Glutathione Peroxidase

Picein is an antioxidant and anti-inflammatory agent. Picein can be isolated from the leaves of Picrorhiza kurroa. Picein reduces MDA levels and increases the levels of SOD, GPX and TAC. Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defects by inhibiting Ferroptosis (via activation of the Nrf2/HO-1/GPX4 pathway). Picein prevents scopolamine (HY-N0296)-induced passive avoidance memory impairment in rats. Picein can be used in research related to osteoporotic bone defects and Alzheimer's disease [1] [2] .
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(Rac)-Salvianic acid A
(Rac)-Salvianic acid A
0 Images
1 Cited Publications
Cat. No.: HY-113145
CAS No.: 23028-17-3
Synonyms: (Rac)-Danshensu; (Rac)-Tanshinol
Category:  

Ketones, Aldehydes, Acids Samanea saman (Jacq.) Merr. Other Diseases Phenols Polyphenols Plants Disease Research Fields Labiatae Extract

Target:  

Drug Isomer

(Rac)-Salvianic acid A ((Rac)-Danshensu) is the racemate of Salvianic acid A (HY-N1913). Salvianic acid A, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research [1] [2] .
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Swertiamarin
Swertiamarin
0 Images
1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Category:  

Monophenols Metabolic Disease Phenols Zanthoxylum chiloperone var. angustifolium Plants Other Families Extract Disease Research Fields Cancer

Target:  

MMP NF-κB JAK Keap1-Nrf2

Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis [1] [2] .
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7-Hydroxyflavone
7-Hydroxyflavone
0 Images
1 Cited Publications
Cat. No.: HY-N7108
CAS No.: 6665-86-7
Category:  

Flavonoids Flavones Plants Verbenaceae Extract Disease Research Fields Inflammation/Immunology Clerodendrum phlomidis

Target:  

ERK Keap1-Nrf2 Apoptosis COX Pyruvate Kinase Lipoxygenase Enterovirus Virus Protease

7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active [1] [2] .
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Maackiain
Maackiain
0 Images
1 Cited Publications
Cat. No.: HY-N0381
CAS No.: 19908-48-6
Synonyms: DL-​Maackiain
Category:  

Infection Natural Products Monophenols Phenols Plants Other Families Extract Disease Research Fields

Target:  

Keap1-Nrf2 p38 MAPK NOD-like Receptor (NLR) NF-κB mTOR Monoamine Oxidase Nuclear Factor of activated T Cells (NFAT) PKC Apoptosis Pyroptosis Autophagy Dengue Virus

Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever [1] [2] 。
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Pinoresinol Diglucoside
Pinoresinol Diglucoside
0 Images
1 Cited Publications
Cat. No.: HY-N0657
CAS No.: 63902-38-5
Category:  

Eucommia ulmoides Oliver Other Diseases Lignans Phenylpropanoids Plants Disease Research Fields Eucommiaceae Extract

Target:  

Free Radical Scavengers NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K

Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis [1] [2] .
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Coniferaldehyde
Coniferaldehyde
0 Images
1 Cited Publications
Cat. No.: HY-N2535
CAS No.: 458-36-6
Synonyms: 4-Hydroxy-3-metHOxycinnamaldehyde
Category:  

Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 Apoptosis

Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities [1].
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