373 Results for "

Nrf2 activation

" in MedChemExpress (MCE) Product Catalog:
Products (373)

373 Results for "Nrf2 activation" in MCE Product Catalog:

4
Sweroside
Sweroside
0 Images
4 Cited Publications
Cat. No.: HY-N0806
CAS No.: 14215-86-2
Category:  

Monophenols Lespedeza tomentosa (Thunb.) Siebold ex Maxim. Metabolic Disease Phenols Plants Disease Research Fields Labiatae Extract

Target:  

Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP

Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .
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Artemisitene
Artemisitene
0 Images
4 Cited Publications
Cat. No.: HY-122550
CAS No.: 101020-89-7
Purity:  99.93%
Category:  

Piscidia erythrina L. Terpenoids Sesquiterpenes Plants Compositae Extract

Target:  

Keap1-Nrf2 Topoisomerase Apoptosis

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability .
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AA147
AA147
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4 Cited Publications
Cat. No.: HY-124293
CAS No.: 393121-74-9
Purity:  99.81%
Target:  

ATF6 Reactive Oxygen Species (ROS)

Research Areas:  

Neurological Disease Metabolic Disease

AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection .
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Isorhapontigenin
Isorhapontigenin
0 Images
4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
Category:  

Gnetaceae Extract Stilbenes Gnetum cleistostachyum C. Y. Cheng Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .
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Gamma-glutamylcysteine
Gamma-glutamylcysteine
0 Images
4 Cited Publications
Cat. No.: HY-113402
CAS No.: 636-58-8
Purity:  95.20%
Synonyms: γ-Glu-Cys
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite Interleukin Related TNF Receptor AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis

Gamma-glutamylcysteine (γ-Glu-Cys) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .
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Gamma-glutamylcysteine TFA
Gamma-glutamylcysteine TFA
0 Images
4 Cited Publications
Cat. No.: HY-113402A
CAS No.: 283159-88-6
Purity:  95.20%
Synonyms: γ-Glu-Cys TFA
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related TNF Receptor Endogenous Metabolite AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis

Gamma-glutamylcysteine TFA (γ-Glu-Cys TFA) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine TFA activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine TFA regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine TFA is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .
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3
Gingerenone A
Gingerenone A
0 Images
3 Cited Publications
Cat. No.: HY-120912
CAS No.: 128700-97-0
Purity:  99.95%
Category:  

Zingiber officinale Roscoe Zingiberaceae Extract Phenols Polyphenols Plants

Target:  

Keap1-Nrf2 Glutathione Peroxidase Ferroptosis

Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice .
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3
CBR-470-1
CBR-470-1
0 Images
3 Cited Publications
Cat. No.: HY-134205A
CAS No.: 2416095-06-0
Purity:  98.02%
Target:  

Keap1-Nrf2

Research Areas:  

Neurological Disease Metabolic Disease

CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .
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Gomisin J
Gomisin J
0 Images
3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Extract Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .
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Phosphocreatine
Phosphocreatine
0 Images
3 Cited Publications
Cat. No.: HY-D0885
CAS No.: 67-07-2
Synonyms: Creatine phosphate; Creatinephosphoric acid
Category:  

Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. .
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Phosphocreatine disodium
Phosphocreatine disodium
0 Images
3 Cited Publications
Cat. No.: HY-D0885B
CAS No.: 922-32-7
Synonyms: Disodium creatine phosphate
Category:  

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. .
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Phosphocreatine disodium hydrate
Phosphocreatine disodium hydrate
0 Images
3 Cited Publications
Cat. No.: HY-D0885D
CAS No.: 19333-65-4
Category:  

Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium hydrate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium hydrate) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium hydrate) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium hydrate) Phosphocreatine (disodium hydrate) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. .
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3
(1R,3R)-RSL3
(1R,3R)-RSL3
0 Images
3 Cited Publications
Cat. No.: HY-100218C
CAS No.: 1219810-15-7
Purity:  99.52%
Target:  

Drug Isomer Ferroptosis

Research Areas:  

Cancer

(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
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Madecassoside
Madecassoside
0 Images
3 Cited Publications
Cat. No.: HY-N0568
CAS No.: 34540-22-2
Synonyms: Asiaticoside A
Category:  

Triterpenes Umbelliferae Extract Terpenoids Other Diseases Centella asiatica (L.) Urb. Plants Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase

Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB , exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.
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3
Monotropein
Monotropein
0 Images
3 Cited Publications
Cat. No.: HY-N0648
CAS No.: 5945-50-6
Category:  

Pyrolaceae Extract Iridoids Pyrola calliantha H. Andr. Terpenoids Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology Rubiaceae Extract

Target:  

Interleukin Related Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Apoptosis

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury .
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Vialinin A
Vialinin A
0 Images
3 Cited Publications
Cat. No.: HY-103435
CAS No.: 858134-23-3
Purity:  99.90%
Synonyms: Terrestrin A
Target:  

Deubiquitinase TNF Receptor E1/E2/E3 Enzyme Keap1-Nrf2

Research Areas:  

Inflammation/Immunology Cancer

Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .
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Nrf2 activator-2
Nrf2 activator-2
0 Images
2 Cited Publications
Cat. No.: HY-145879
CAS No.: 2770448-53-6
Purity:  99.20%
Target:  

Keap1-Nrf2

Research Areas:  

Cancer

Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research .
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Monoethyl fumarate
Monoethyl fumarate
0 Images
2 Cited Publications
Cat. No.: HY-W019696
CAS No.: 2459-05-4
Target:  

Keap1-Nrf2

Research Areas:  

Inflammation/Immunology

Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883). Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material .
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(+)-DHMEQ
(+)-DHMEQ
0 Images
2 Cited Publications
Cat. No.: HY-14645A
CAS No.: 287194-41-6
Purity:  99.33%
Synonyms: (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ
Target:  

Keap1-Nrf2

Research Areas:  

Inflammation/Immunology

(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.
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5,7-Dihydroxychromone
5,7-Dihydroxychromone
0 Images
2 Cited Publications
Cat. No.: HY-N1970
CAS No.: 31721-94-5
Category:  

Flavonoids Phenols Polyphenols Plants Other Families Extract Isoflavones

Target:  

Keap1-Nrf2 Caspase PARP Fungal

5,7-Dihydroxychromone is a flavonoid compound with antioxidant properties. 5,7-Dihydroxychromone induces Nrf2 nuclear translocation, increases Nrf2/ARE binding activity, and up-regulates Nrf2-dependent antioxidant genes HO-1, NQO1, GCLc. 5,7-Dihydroxychromone attenuates excessive ROS generation, inhibits activated caspase-3, caspase-9, cleaved PARP expression, and prevents neuronal apoptosis and cell death. 5,7-Dihydroxychromone increases LXRα and PPARγ mRNA expression, induces preadipocyte differentiation, and regulates blood glucose levels. 5,7-Dihydroxychromone inhibits radial growth of soil pathogenic fungi, radicle elongation of select seedlings, and transiently inhibits Bradyrhizobium sp. growth in high mannitol medium. 5,7-Dihydroxychromone can be used for the research of Parkinson’s disease, type 2 diabetes mellitus and pathogenic fungal infection .
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