1013 Results for "

Content uniformity test

" in MedChemExpress (MCE) Product Catalog:
Products (1013)

1013 Results for "Content uniformity test" in MCE Product Catalog:

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1 Cited Publications
Cat. No.: HY-P1746
CAS No.: 121545-65-1
Synonyms: PKC (19-31)
Target:  

PKC

Research Areas:  

Inflammation/Immunology

Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .
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1 Cited Publications
Cat. No.: HY-D0018
CAS No.: 620-45-1
Synonyms: Dichlorophenylindophenol sodium; DCPIP sodium; Indochlorophenol sodium
DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. DCIP sodium has unique chemical properties that change color according to the oxidation state of the substance being tested. It is commonly used in enzyme assays, such as measuring the activity of succinate dehydrogenase, or in protein quantification methods, such as the Lowry assay.
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1 Cited Publications
Cat. No.: HY-P2799A
CAS No.: 9001-15-4
Synonyms: CK, CPK, Creatine Phosphokinase
Creatine Kinase (CPK/CK), Bovine Heart (CK) is a creatine kinase derived from bovine heart. Creatine Kinase (CPK/CK), Bovine Heart catalyzes the reversible phosphate transfer reaction between phosphocreatine and ADP, and is widely used in myocardial energy metabolism research and quality control of clinical biochemical tests .
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1 Cited Publications
Cat. No.: HY-147246
CAS No.: 1868138-66-2
Purity:  99.34%
Synonyms: HTD1801; BUDCA
Research Areas:  

Metabolic Disease

Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes .
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1 Cited Publications
Cat. No.: HY-19796
CAS No.: 246529-22-6
Synonyms: Aramchol; C20-FABAC
Research Areas:  

Metabolic Disease

Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) .
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1 Cited Publications
Cat. No.: HY-23155
CAS No.: 2257-09-2
Synonyms: 2-PE ITC
Target:  

Fungal

Research Areas:  

Infection

2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternate might be via reduction in toxin content and breakdown of cell membrane integrity .
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1 Cited Publications
Cat. No.: HY-D0945
CAS No.: 2650-17-1
Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested .
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1 Cited Publications
Cat. No.: HY-131335
CAS No.: 1095003-80-7
Purity:  98.03%
Target:  

p38 MAPK

Research Areas:  

Inflammation/Immunology

p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets .
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1 Cited Publications
Cat. No.: HY-W011215
CAS No.: 84-75-3
Dihexyl phthalate is an orally active phthalate ester (PAEs) widely used as a plasticizer, and it acts as an environmental endocrine disruptor. Dihexyl phthalate exhibits endocrine-disrupting and reproductive toxic properties, induces oxidative stress and inflammation, and ultimately causes apoptosis and damage to reproductive organs such as the testes. Dihexyl phthalate can be used in studies related to developmental toxicity, embryonic lethality, teratogenicity, and abnormal development of the male reproductive system .
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1 Cited Publications
Cat. No.: HY-113085
CAS No.: 1637-75-8
Purity:  99.83%
3-Hydroxyhippuric acid is an acylglycine. 3-Hydroxyhippuric acid inhibits kynureninase (Ki=60 μM). The concentration of 3-Hydroxyhippuric acid in autistic experimental groups is higher than that in control groups. 3-Hydroxyhippuric acid is a biomarker for Clostridium and is positively correlated with the content of Clostridium. 3-Hydroxyhippuric acid is one of the major metabolites of catechin-rich and wine polyphenol-rich diets. 3-Hydroxyhippuric acid can be used in the research of neurodegenerative diseases and autism spectrum disorders .
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1 Cited Publications
Cat. No.: HY-14196
CAS No.: 29218-27-7
Purity:  98.11%
Synonyms: MD 69276
Target:  

Monoamine Oxidase

Research Areas:  

Neurological Disease

Toloxatone (MD 69276) is a reversible, selective MAO-A inhibitor that can cross the blood-brain barrier. Toloxatone increases the levels of serotonin (5-HT) and norepinephrine in the brain. Toloxatone reduces the immobility time in the forced swimming test in mice, inhibits killing behavior in rats without causing sedation, and shows a correlation between its free plasma concentration and cerebrospinal fluid concentration. Toloxatone is widely used in research related to depression, depressive disorders and Parkinson's disease .
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1 Cited Publications
Cat. No.: HY-N3017
CAS No.: 479-90-3
Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED50 of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED50 of 1.6 μg/kg, and has analgesic activity .
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1 Cited Publications
Cat. No.: HY-W105970
CAS No.: 7758-16-9
Synonyms: Disodium pyrophosphate; Sodium acid pyrophosphate; SAPP
Sodium pyrophosphate (Disodium pyrophosphate) is an orally active reverse transcriptase ribonuclease H inhibitor. Sodium pyrophosphate forms soluble complexes with iron from ferric pyrophosphate to promote intestinal iron absorption. Sodium pyrophosphate increases the β-sheet content of oxidatively damaged myofibrillar protein gels and enhances the gastric digestibility and antioxidant activity of their digestion products. Sodium pyrophosphate prevents the degradation of RNA-DNA hybrids, inhibits antisense complementary DNA synthesis, induces phage DNA leakage, and causes random mutations in temperate phages .
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1 Cited Publications
Cat. No.: HY-W540188A
Synonyms: Ketomalonic acid calcium trihydrate; Mesoxalic acid calcium trihydrate; Oxomalonic acid calcium trihydrate
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Calcium mesoxalate trihydrate (Ketomalonic acid calcium trihydrate) is an orally active antidiabetic agent. Calcium mesoxalate trihydrate increases pancreatic insulin content. Calcium mesoxalate trihydrate reduces dietary hyperglycemia. Calcium mesoxalate trihydrate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Calcium mesoxalate trihydrate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Calcium mesoxalate trihydrate can be used in diabetes-related research .
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1 Cited Publications
Cat. No.: HY-131146
CAS No.: 43056-63-9
Purity:  99.89%
Synonyms: 3-Amino-5-morpholinomethyl-2-oxazolidone
Target:  

Drug Metabolite

Research Areas:  

Infection

AMOZ is a carcinogenic metabolite of Furaltadone (HY-B1148A), which forms stable tissue residues by covalently binding to proteins as a hapten. AMOZ can be coupled with carrier proteins (such as BSA/OVA) to induce immune response and is released after acid hydrolysis. AMOZ residues can be detected by competitive ELISA method, and the detection limit in the monoclonal antibody 2E5.1 test is as low as 0.16 μg/kg (shrimp sample). AMOZ can be used as a typical marker to monitor drug residues in animal-derived foods in the field of food safety[1][2].
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1 Cited Publications
Cat. No.: HY-P1441A
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
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1 Cited Publications
Cat. No.: HY-15929
CAS No.: 14348-40-4
Synonyms: 2,4,6-Tribromo-3-hydroxybenzoic acid
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
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1 Cited Publications
Cat. No.: HY-N7694
CAS No.: 97871-44-8
Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation .
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1 Cited Publications
Cat. No.: HY-Y0678
CAS No.: 621-23-8
Synonyms: TRIMETHYL PHLOROGLUCINOL
1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl +) and free bromine (Br +). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
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1 Cited Publications
Cat. No.: HY-N1437
CAS No.: 6205-14-7
Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .
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